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Recent Citations

Structural basis of the day-night transition in a bacterial circadian clock. Tseng R, Goularte NF et al. Science. 2017 Mar 17;355(6330):1174-1180.

Structures of the cyanobacterial circadian oscillator frozen in a fully assembled state. Snijder J, Schuller JM et al. Science. 2017 Mar 17;355(6330):1181-1184.

Double-stranded RNA virus outer shell assembly by bona fide domain-swapping. Sun Z, El Omari K et al. Nat Commun. 2017 Mar 13;8:14814.

Molecular architecture of the major membrane ring component of the nuclear pore complex. Upla P, Kim SJ et al. Structure. 2017 Mar 7;25(3):434-445.

Self-assembly of nanoparticles into biomimetic capsid-like nanoshells. Yang M, Chan H et al. Nat Chem. 2017 Mar;9(3):287-294.

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Chimera Search

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December 2, 2016

Chimera production release 1.11.2 is now available. This version has been updated to work with changes in NCBI Blast and to avoid crashes on Mac Sierra (see the release notes for details).

September 24, 2016

Production release candidate (version 1.11.2) is available, superseding 1.11.1. The new version has been updated to work with changes in NCBI Blast (see release notes). Please try it and report any problems.

August 27, 2016

A production release candidate (version 1.11.1) is now available. Please try it and report any problems. See the release notes for what's been fixed since 1.11. The 1.11 release series will be the last to support 32-bit builds.

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Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, nonprofit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), funded by the National Institutes of Health (NIGMS P41-GM103311).

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the RBVI, following UCSF Chimera.

Feature Highlight

ribbon spline comparison

Ribbon Spline Options

The default ribbon path is a smooth bspline (semitransparent tan in the figure), which can diverge from the true positions of the backbone atoms (α-carbons shown as gray balls). A cardinal spline allows tracking the backbone more closely. Without smoothing (light blue), it follows the α-carbons exactly, or it can be combined with some “compromise” smoothing of strand and/or coil. Ribbon spline options can be set with the ribspline command or in the molecule model attributes.

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Gallery Sample

Orexin Receptor Complex

The image shows the structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant, Protein Data Bank entry 4s0v. The drug is shown as spheres colored by element, and the receptor as ribbons with secondary structure elements rainbow-colored from blue at the N-terminus to red at the C-terminus. (More samples...)