Escape from bacterial iron piracy through rapid evolution of transferrin. Barber MF, Elde NC. Science. 2014 Dec 12;346(6215):1362-6.
Ultrastable gold substrates for electron cryomicroscopy. Russo CJ, Passmore LA. Science. 2014 Dec 12;346(6215):1377-80.
Cryo-electron tomography reveals ciliary defects underlying human RSPH1 primary ciliary dyskinesia. Lin J, Yin W et al. Nat Commun. 2014 Dec 4;5:5727.
Structures of protective antibodies reveal sites of vulnerability on Ebola virus. Murin CD, Fusco ML et al. Proc Natl Acad Sci USA. 2014 Dec 2;111(48):17182-7.
Structure of a designed protein cage that self-assembles into a highly porous cube. Lai YT, Reading E et al. Nat Chem. 2014 Dec;6(12):1065-71.(Previously featured citations...)
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November 5, 2014
Chimera production release 1.10 is now available. 64-bit builds are recommended for all capable platforms, and v1.10 will be the last to support OS X 10.6 and 10.7. See the release notes for what's new.
October 23, 2014
A production release candidate (v1.10) is available; please try it and report any problems. 64-bit builds are now recommended for all capable platforms, and v1.10 will be the last to support OS X 10.6 and 10.7. See the release notes for what's new.
August 15, 2014
We are delighted to announce the publication of a new book, Computational and Visualization Techniques for Structural Bioinformatics Using Chimera, written by Forbes J. Burkowski (University of Waterloo).(Previous news...)
UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, non-profit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics, funded by the National Institutes of Health (NIGMS P41-GM103311).
The Multalign Viewer
tool displays individual sequences and multiple sequence alignments.
Sequence alignments can be read from external files
formats) or created by other tools in Chimera.
Structures opened in Chimera are automatically associated
with sufficiently similar sequences in the alignment. After association,
mousing over a residue in the sequence shows its structure residue number
selecting in the sequence selects residues in the structure(s) and vice versa
structures can be superimposed using the sequence alignment
Various measures of sequence conservation and structural variation (RMSD) can be computed and shown above the sequences as histograms, and on the structures with color or worm radius. Secondary structure elements can be depicted as colored boxes or regions on the alignment. Regions can also be created by hand.