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Noncanonical agonist-dependent and -independent arrestin recruitment of GPR1. Cai H, Lin X et al. Science. 2025 Nov 20;390(6775):eadt8794.

High-resolution cryo-EM analysis of the therapeutic Pseudomonas phage Pa223. Hou CD, Bellis N et al. J Mol Biol. 2025 Nov 1;437(21):169386.

How augmin establishes the angle of the microtubule branch site. Travis SM, Kraus J et al. Nat Commun. 2025 Oct 31;16(1):9646.

Oligomeric HIV-1 integrase structures reveal functional plasticity for intasome assembly and RNA binding. Jing T, Shan Z et al. Nat Commun. 2025 Oct 24;16(1):9430.

Crystal structures of agonist-bound human cannabinoid receptor CB1. Hua T, Vemuri K et al. Nature. 2025 Oct 16;646(8085):754–758.

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News

September 22, 2025

Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.

March 6, 2025

Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (details...).

December 25, 2024

The RBVI wishes you a safe and happy holiday season! See our 2024 card and the gallery of previous cards back to 1985.

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Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

Volume Data

Volume Data

Chimera's Volume Viewer displays three-dimensional electron and light microscope data, X-ray density maps, electrostatic potential and other volumetric data. Contour surfaces, meshes and volumetric display styles are provided and thresholds can be changed interactively. Maps can be colored, sliced, segmented, and modifications can be saved. Markers can be placed and structures can be traced. The accompanying image shows a density map of Kelp fly virus from electron microscopy colored radially and with an octant cut out.

(More features...)

Gallery Sample

Wasabi Receptor

The image shows the structure of the human TRPA1 ion channel (wasabi receptor) determined by electron cryo-microscopy, Protein Data Bank entry 3j9p. The four subunits of the tetramer are shown as ribbons in different colors over a dark-to-light gradient background. (More samples...)


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