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Recent Citations

Structural basis of tankyrase activation by polymerization. Pillay N, Mariotti L et al. Nature. 2022 Dec 1;612(7938):162–169.

Recognition of cyclic dinucleotides and folates by human SLC19A1. Zhang Q, Zhang X et al. Nature. 2022 Dec 1;612(7938):170–176.

Three-dimensional flagella structures from animals' closest unicellular relatives, the Choanoflagellates. Pinskey JM, Lagisetty A et al. eLife. 2022 Nov 17;11:e78133.

TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand. Lim CS, Jang YH et al. Nat Commun. 2022 Nov 12;13(1):6876.

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages. Park YJ, Pinto D et al. Science. 2022 Nov 11;378(6620):619-627.

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September 27, 2022

Website downtime: The RBVI website (Chimera, ChimeraX, etc.) and RBVI-hosted web services will be down for maintenance from Tue, Sep 27 9pm PDT, through Wed, possibly extending to Thu, Sep 29 5pm PDT.

December 20, 2021

The RBVI wishes you a safe and happy holiday season! See our 2021 card and the gallery of previous cards back to 1985.

December 17, 2021

Chimera production release 1.16 is now available. This will be the last release to support Windows 7. See the release notes for what's new.

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Upcoming Events

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features. ChimeraX includes a significant subset of Chimera features (with more to come, see the missing features list) and is under active development. Users may choose to use both programs, and it is fine to have both installed.

Chimera is no longer under active development, and is only updated for critical maintenance. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

ribbon spline comparison

Ribbon Spline Options

The default ribbon path is a smooth bspline (semitransparent tan in the figure), which can diverge from the true positions of the backbone atoms (α-carbons shown as gray balls). A cardinal spline allows tracking the backbone more closely. Without smoothing (light blue), it follows the α-carbons exactly, or it can be combined with some “compromise” smoothing of strand and/or coil. Ribbon spline options can be set with the ribspline command or in the molecule model attributes.

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Gallery Sample

Peroxiredoxin Wreath

Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.

See also the RBVI holiday card gallery.

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