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The molecular basis of force selectivity by PIEZO2. Mulhall EM, Yarishkin O et al. Nature. 2026 May 7;653(8113):297–305.
Human DHX29 detects nonoptimal codon usage to regulate mRNA stability. Hia F, Wu Y et al. Science. 2026 May 7;392(6798):eadw0288.
CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome. Shi H, Wang X et al. Nature. 2026 Apr 30;652(8112):1375–1383.
Complement inhibition by a unique cluster of immunomodulatory outer surface proteins of Borrelia recurrentis. Röttgerding F, Reyer F et al. Nat Commun. 2026 Apr 29;17(1):3900.
Pre-incision structures reveal principles of DNA nucleotide excision repair. Li ECL, Kim J et al. Nature. 2026 Apr 23;652(8111):1060–1067.
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December 25, 2025
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September 22, 2025
Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.
March 6, 2025
Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (1.19 release notes).
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.
We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).
Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.
Feature Highlight
The default ribbon path is a smooth bspline (semitransparent tan in the figure), which can diverge from the true positions of the backbone atoms (α-carbons shown as gray balls). A cardinal spline allows tracking the backbone more closely. Without smoothing (light blue), it follows the α-carbons exactly, or it can be combined with some “compromise” smoothing of strand and/or coil. Ribbon spline options can be set with the ribspline command or in the molecule model attributes.
(More features...)
Gallery Sample
Potassium channel (Protein Data Bank entry 1bl8) on a dark slate blue background with potassium ions shown in firebrick. The channel is comprised of four chains. Each chain has been rainbow-colored from blue at the N-terminus to red at the C-terminus, but only the surface of the channel is shown. The surface has been sliced with a per-model clipping plane. The surface cap color is plum except with opacity set to 0.8. The shininess and brightness have been set to 128 and 8, respectively, and the lights on the scene have been moved from their default positions. The subdivision quality (related to the smoothness of the spherical ions) is 5.0, and the molecular surface was computed with probe radius and vertex density set to 1.0 and 6.0, respectively. (More samples...)
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