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Recent Citations
Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling. Mogila I, Tamulaitiene G et al. Science. 2023 Dec 1;382(6674):1036-1041.
Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2. Pidathala S, Liao S et al. Nature. 2023 Nov 30;623(7989):1086-1092.
Mechanism of target site selection by type V-K CRISPR-associated transposases. George JT, Acree C et al. Science. 2023 Nov 17;382(6672):eadj8543.
A practical guide to machine-learning scoring for structure-based virtual screening. Tran-Nguyen VK, Junaid M et al. Nat Protoc. 2023 Nov;18(11):3460-3511.
Structure and activation mechanism of the rice Salt Overly Sensitive 1 (SOS1) Na+/H+ antiporter. Zhang XY, Tang LH et al. Nat Plants. 2023 Nov;9(11):1924-1936.
Previously featured citations...Chimera Search
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October 30-31, 2023
Planned downtime: The Chimera and ChimeraX websites and associated web services will be unavailable Oct 30 8am PDT – Oct 31 11:59pm PDT.
April 19, 2023
Chimera production release 1.17.1 is now available, fixing an issue with 1.17 for Windows and Linux. See the release notes for details.
April 13, 2023
Chimera production release 1.17 is now available. Updating is required to keep using the tools that run Blast Protein, Modeller, and multiple sequence alignment with Clustal Omega or MUSCLE, as these will soon stop working in older versions. See the release notes for details.
Previous news...Upcoming Events
UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.
We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).
Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.
Feature Highlight
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A structure can be colored to show attributes such as residue conservation. Opening a sequence alignment in Chimera shows it in Multalign Viewer and automatically associates sequences with structures as appropriate. Residues of alignment-associated structures are assigned conservation values; available measures include entropy, variability, and sum-of-pairs. The figure was created using the PFAM Carb_anhydrase seed alignment PF00194_seed.slx (see image) and includes 2D labels and a color key. See also: mapping sequence conservation
(More features...)Gallery Sample
Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.
See also the RBVI holiday card gallery.
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