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Recent Citations

Escape from bacterial iron piracy through rapid evolution of transferrin. Barber MF, Elde NC. Science. 2014 Dec 12;346(6215):1362-6.

Ultrastable gold substrates for electron cryomicroscopy. Russo CJ, Passmore LA. Science. 2014 Dec 12;346(6215):1377-80.

Cryo-electron tomography reveals ciliary defects underlying human RSPH1 primary ciliary dyskinesia. Lin J, Yin W et al. Nat Commun. 2014 Dec 4;5:5727.

Structures of protective antibodies reveal sites of vulnerability on Ebola virus. Murin CD, Fusco ML et al. Proc Natl Acad Sci USA. 2014 Dec 2;111(48):17182-7.

Structure of a designed protein cage that self-assembles into a highly porous cube. Lai YT, Reading E et al. Nat Chem. 2014 Dec;6(12):1065-71.

(Previously featured citations...)

Chimera Search

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News

November 5, 2014

Chimera production release 1.10 is now available. 64-bit builds are recommended for all capable platforms, and v1.10 will be the last to support OS X 10.6 and 10.7. See the release notes for what's new.

October 23, 2014

A production release candidate (v1.10) is available; please try it and report any problems. 64-bit builds are now recommended for all capable platforms, and v1.10 will be the last to support OS X 10.6 and 10.7. See the release notes for what's new.

August 15, 2014

We are delighted to announce the publication of a new book, Computational and Visualization Techniques for Structural Bioinformatics Using Chimera, written by Forbes J. Burkowski (University of Waterloo).

(Previous news...)

Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, non-profit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics, funded by the National Institutes of Health (NIGMS P41-GM103311).

Feature Highlight

sequence structure

Sequence Viewer

The Multalign Viewer tool displays individual sequences and multiple sequence alignments. Sequence alignments can be read from external files (several formats) or created by other tools in Chimera. Structures opened in Chimera are automatically associated with sufficiently similar sequences in the alignment. After association,
   • mousing over a residue in the sequence shows its structure residue number
   • selecting in the sequence selects residues in the structure(s) and vice versa
   • structures can be superimposed using the sequence alignment
Various measures of sequence conservation and structural variation (RMSD) can be computed and shown above the sequences as histograms, and on the structures with color or worm radius. Secondary structure elements can be depicted as colored boxes or regions on the alignment. Regions can also be created by hand.

(More features...)

Gallery Sample

Molecular Bracelet

Eukaryotic initiation factor (eIF) complex (from Protein Data Bank entry 1rf8) in which eIF4E, shown with blue ribbons, is completely encircled by eIF4G, shown with yellow ribbons and red molecular surface (image creation details). (More samples...)