about projects people publications resources resources visit us visit us search search

Quick Links

Chimera Search

Google™ Search

Citations (partial list)

Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex. Zhu X, Huang G et al. Science. 2022 Jun 10;376(6598):eabl8280.

Architecture of the cytoplasmic face of the nuclear pore. Bley CJ, Nie S et al. Science. 2022 Jun 10;376(6598):eabm9129.

Architecture of the linker-scaffold in the nuclear pore. Petrovic S, Samanta D et al. Science. 2022 Jun 10;376(6598):eabm9798.

Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses. He WT, Musharrafieh R et al. Nat Immunol. 2022 Jun;23(6):960-970.

A feature-guided, focused 3D signal permutation method for subtomogram averaging. Peters JJ, Leitz J et al. J Struct Biol. 2022 Jun;214(2):107851.

Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes. Wang C, Hesketh EL et al. Nat Commun. 2022 May 25;13(1):2921.

Posttranslational modification of microtubules by the MATCAP detyrosinase. Landskron L, Bak J et al. Science. 2022 May 20;376(6595):eabn6020.

Opening of glutamate receptor channel to subconductance levels. Yelshanskaya MV, Patel DS et al. Nature. 2022 May 5;605(7908):172-178.

Novel fold of rotavirus glycan-binding domain predicted by AlphaFold2 and determined by X-ray crystallography. Hu L, Salmen W et al. Commun Biol. 2022 May 5;5(1):419.

Cryo-EM structure of an active central apparatus. Han L, Rao Q et al. Nat Struct Mol Biol. 2022 May;29(5):472-482.

Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition. Shaban NM, Yan R et al. Sci Adv. 2022 Apr 29;8(17):eabm2827.

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1. Qu X, Qiu N et al. Nature. 2022 Apr 28;604(7907):779–785.

Three-dimensional structure determination of protein complexes using matrix-landing mass spectrometry. Westphall MS, Lee KW et al. Nat Commun. 2022 Apr 27;13(1):2276.

Computational design of mechanically coupled axle-rotor protein assemblies. Courbet A, Hansen J et al. Science. 2022 Apr 22;376(6591):383-390.

Activation of STING by targeting a pocket in the transmembrane domain. Lu D, Shang G et al. Nature. 2022 Apr 21;604(7906):557–562.

Molecular basis of receptor binding and antibody neutralization of Omicron. Hong Q, Han W et al. Nature. 2022 Apr 21;604(7906):546–552.

Structure deformation and curvature sensing of PIEZO1 in lipid membranes. Yang X, Lin C et al. Nature. 2022 Apr 14;604(7905):377–383.

Structure, substrate recognition and initiation of hyaluronan synthase. Maloney FP, Kuklewicz J et al. Nature. 2022 Apr 7;604(7904):195–201.

Identification of functional substates of KRas during GTP hydrolysis with enhanced sampling simulations. Zeng J, Chen J et al. Phys Chem Chem Phys. 2022 Mar 30;24(13):7653-7665.

SINAPs: A software tool for analysis and visualization of interaction networks of molecular dynamics simulations. Bedart C, Renault N et al. J Chem Inf Model. 2022 Mar 28;62(6):1425-1436.

A structural basis for amylin receptor phenotype. Cao J, Belousoff MJ et al. Science. 2022 Mar 25;375(6587):eabm9609.

Activation mechanism of the class D fungal GPCR dimer Ste2. Velazhahan V, Ma N et al. Nature. 2022 Mar 24;603(7902):743-748.

Concise syntheses of GB22, GB13, and himgaline by cross-coupling and complete reduction. Landwehr EM, Baker MA et al. Science. 2022 Mar 18;375(6586):1270-1274.

Discovery of a Ni2+-dependent guanidine hydrolase in bacteria. Funck D, Sinn M et al. Nature. 2022 Mar 17;603(7901):515–521.

Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue. Cerullo F, Filbeck S et al. Nature. 2022 Mar 17;603(7901):509–514.

Cryo-EM structure and electrophysiological characterization of ALMT from Glycine max reveal a previously uncharacterized class of anion channels. Qin L, Tang LH et al. Sci Adv. 2022 Mar 4;8(9):eabm3238.

Structure and receptor recognition by the Lassa virus spike complex. Katz M, Weinstein J et al. Nature. 2022 Mar 3;603(7899):174-179.

Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Sverzhinsky A, Tomkinson AE, Pascal JM. Structure. 2022 Mar 3;30(3):371-385.e5.

Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting. Jomaa A, Gamerdinger M et al. Science. 2022 Feb 25;375(6583):839-844.

Visualizing protein breathing motions associated with aromatic ring flipping. Mariño Pérez L, Ielasi FS et al. Nature. 2022 Feb 24;602(7898):695-700.

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex. Mannar D, Saville JW et al. Science. 2022 Feb 18;375(6582):760-764.

Mechanisms of inhibition and activation of extrasynaptic αβ GABA(A) receptors. Kasaragod VB, Mortensen M et al. Nature. 2022 Feb 17;602(7897):529-533.

Broadly neutralizing antibodies target a haemagglutinin anchor epitope. Guthmiller JJ, Han J et al. Nature. 2022 Feb 10;602(7896):314–320.

Acid-stable capsid structure of Helicobacter pylori bacteriophage KHP30 by single-particle cryoelectron microscopy. Kamiya R, Uchiyama J et al. Structure. 2022 Feb 3;30(2):300-312.e3.

The amyloid concentric β-barrel hypothesis: Models of synuclein oligomers, annular protofibrils, lipoproteins, and transmembrane channels. Durell SR, Guy HR. Proteins. 2022 Feb;90(2):512-542.

Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs. Liang S, Thomas SE et al. Nature. 2022 Jan 27;601(7894):643–648.

Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding. Martinez Fiesco JA, Durrant DE et al. Nat Commun. 2022 Jan 25;13(1):486.

From structure to sequence: Antibody discovery using cryoEM. Antanasijevic A, Bowman CA et al. Sci Adv. 2022 Jan 21;8(3):eabk2039.

Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Wang RY, Noddings CM et al. Nature. 2022 Jan 20;601(7893):460–464.

Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Akey CW, Singh D et al. Cell. 2022 Jan 20;185(2):361-378.e25.

Structure and mechanism of the SGLT family of glucose transporters. Han L, Qu Q et al. Nature. 2022 Jan 13;601(7892):274–279.

Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex. Patil DN, Singh S et al. Science. 2022 Jan 7;375(6576):86-91.

Leveraging crosslinking mass spectrometry in structural and cell biology. Graziadei A, Rappsilber J. Structure. 2022 Jan 6;30(1):37-54.

Integrative structural modeling of macromolecular complexes using Assembline. Rantos V, Karius K, Kosinski J. Nat Protoc. 2022 Jan;17(1):152-176.

Structure and plasticity of indoleamine 2,3-dioxygenase 1 (IDO1). Röhrig UF, Michielin O, Zoete V. J Med Chem. 2021 Dec 23;64(24):17690-17705.

Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2. Fukudome A, Singh J et al. Proc Natl Acad Sci USA. 2021 Dec 21;118(51):e2115899118.

The conformational cycle of prestin underlies outer-hair cell electromotility. Bavi N, Clark MD et al. Nature. 2021 Dec 16;600(7889):553–558.

Computed structures of core eukaryotic protein complexes. Humphreys IR, Pei J et al. Science. 2021 Dec 10;374(6573):eabm4805.

Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface. Diwanji D, Trenker R et al. Nature. 2021 Dec 9;600(7888):339–343.

Structure, function and pharmacology of human itch receptor complexes. Yang F, Guo L et al. Nature. 2021 Dec 2;600(7887):164–169.

The human microbiome encodes resistance to the antidiabetic drug acarbose. Balaich J, Estrella M et al. Nature. 2021 Dec 2;600(7887):110-115.

Molecular structure of an open human KATP channel. Zhao C, MacKinnon R. Proc Natl Acad Sci USA. 2021 Nov 30;118(48):e2112267118.

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. Meng Y, Davies KA et al. Nat Commun. 2021 Nov 22;12(1):6783.

A viral RNA hijacks host machinery using dynamic conformational changes of a tRNA-like structure. Bonilla SL, Sherlock ME et al. Science. 2021 Nov 19;374(6570):955-960.

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. de Almeida M, Hinterndorfer M et al. Nature. 2021 Nov 18;599(7885):491-496.

Kainate receptor modulation by NETO2. He L, Sun J et al. Nature. 2021 Nov 11;599(7884):325-329.

Dispatched uses Na+ flux to power release of lipid-modified Hedgehog. Wang Q, Asarnow DE et al. Nature. 2021 Nov 11;599(7884):320-324.

Mapping the catalytic conformations of an assembly-line polyketide synthase module. Cogan DP, Zhang K et al. Science. 2021 Nov 5;374(6568):729-734.

Bluetongue virus capsid protein VP5 perforates membranes at low endosomal pH during viral entry. Xia X, Wu W et al. Nat Microbiol. 2021 Nov;6(11):1424-1432.

The cellular environment shapes the nuclear pore complex architecture. Schuller AP, Wojtynek M et al. Nature. 2021 Oct 28;598(7882):667–671.

Pan-ebolavirus protective therapy by two multifunctional human antibodies. Gilchuk P, Murin CD et al. Cell. 2021 Oct 28;184(22):5593-5607.e18.

Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas. Hu C, Almendros C et al. Nature. 2021 Oct 21;598(7881):515-520.

Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA. Anso I, Basso LGM et al. Sci Adv. 2021 Oct 15;7(42):eabj4565.

Structural basis of human transcription-DNA repair coupling. Kokic G, Wagner FR et al. Nature. 2021 Oct 14;598(7880):368-372.

The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes. Tran NH, Carter SD et al. Science. 2021 Oct 1;374(6563):52-57.

A practical guide to large-scale docking. Bender BJ, Gahbauer S et al. Nat Protoc. 2021 Oct;16(10):4799-4832.

The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes. Sakuragi T, Kanai R et al. Nat Struct Mol Biol. 2021 Oct;28(10):825-834.

Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations. Abe K, Yamamoto K et al. Nat Commun. 2021 Sep 29;12(1):5709.

Structural insights into the inhibition of undecaprenyl pyrophosphate synthase from Gram-positive bacteria. Workman SD, Day J et al. J Med Chem. 2021 Sep 23;64(18):13540-13550.

Cryo-EM structure of the Rhodospirillum rubrum RC-LH1 complex at 2.5 Å. Qian P, Croll TI et al. Biochem J. 2021 Sep 17;478(17):3253-3263.

Structural basis of RNA polymerase inhibition by viral and host factors. Pilotto S, Fouqueau T et al. Nat Commun. 2021 Sep 17;12(1):5523.

Structure of Geobacter pili reveals secretory rather than nanowire behaviour. Gu Y, Srikanth V et al. Nature. 2021 Sep 16;597(7876):430-434.

In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli. Erdmann PS, Hou Z et al. Nat Commun. 2021 Sep 10;12(1):5364.

Broad betacoronavirus neutralization by a stem helix-specific human antibody. Pinto D, Sauer MM et al. Science. 2021 Sep 3;373(6559):1109-1116.

Evolving cryo-EM structural approaches for GPCR drug discovery. Zhang X, Johnson RM et al. Structure. 2021 Sep 2;29(9):963-974.e6.

Molecular mechanism of prestin electromotive signal amplification. Ge J, Elferich J et al. Cell. 2021 Sep 2;184(18):4669-4679.e13.

Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM. Sun M, Azumaya CM et al. J Struct Biol. 2021 Sep;213(3):107745.

Structural basis of RNA processing by human mitochondrial RNase P. Bhatta A, Dienemann C et al. Nat Struct Mol Biol. 2021 Sep;28(9):713-723.

Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. Su Z, Zhang K et al. Nature. 2021 Aug 26;596(7873):603-607.

Ankyrin repeats in context with human population variation. Utgés JS, Tsenkov MI et al. PLoS Comput Biol. 2021 Aug 24;17(8):e1009335.

Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Hu Q, Botuyan MV et al. Nature. 2021 Aug 19;596(7872):438-443.

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants. Yuan M, Huang D et al. Science. 2021 Aug 13;373(6556):eabh1139.

Chromosome modeling on downsampled Hi-C maps enhances the compartmentalization signal. Oliveira Junior AB, Estrada CP et al. J Phys Chem B. 2021 Aug 12;125(31):8757-8767.

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM. Antanasijevic A, Sewall LM et al. Nat Commun. 2021 Aug 10;12(1):4817.

Maturation of the matrix and viral membrane of HIV-1. Qu K, Ke Z et al. Science. 2021 Aug 6;373(6555):700-704.

Gold nanoparticles and tilt pairs to assess protein flexibility by cryo-electron microscopy. Jagota M, Townshend RJL et al. Ultramicroscopy. 2021 Aug;227:113302.

Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch. Dai L, Xu K et al. Nat Immunol. 2021 Aug;22(8):958-968.

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Yu Q, Ni D et al. Nat Commun. 2021 Jul 19;12(1):4376.

Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells. Zhang J, Wang H et al. Cell Discov. 2021 Jul 13;7(1):51.

PspA adopts an ESCRT-III-like fold and remodels bacterial membranes. Junglas B, Huber ST et al. Cell. 2021 Jul 8;184(14):3674-3688.e18.

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates. Galaz-Montoya JG, Shahmoradian SH et al. Commun Biol. 2021 Jul 8;4(1):849.

Structural basis of omega-3 fatty acid transport across the blood-brain barrier. Cater RJ, Chua GL et al. Nature. 2021 Jul 8;595(7866):315-319.

High-resolution crystal structures of transient intermediates in the phytochrome photocycle. Carrillo M, Pandey S et al. Structure. 2021 Jul 1;29(7):743-754.e4.

Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry. Felker D, Zhang H et al. Biophys Chem. 2021 Jul;274:106590.

Structures of G(i)-bound metabotropic glutamate receptors mGlu2 and mGlu4. Lin S, Han S et al. Nature. 2021 Jun 24;594(7864):583-588.

Structures of human mGlu2 and mGlu7 homo- and heterodimers. Du J, Wang D et al. Nature. 2021 Jun 24;594(7864):589-593.

IonoBiology: The functional dynamics of the intracellular metallome, with lessons from bacteria. Galera-Laporta L, Comerci CJ et al. Cell Syst. 2021 Jun 16;12(6):497-508.

Structures of the human Mediator and Mediator-bound preinitiation complex. Chen X, Yin X et al. Science. 2021 Jun 4;372(6546):eabg0635.

Structure of the merozoite surface protein 1 from Plasmodium falciparum. Dijkman PM, Marzluf T et al. Sci Adv. 2021 Jun 2;7(23):eabg0465.

Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer. Staquicini FI, Hajitou A et al. eLife. 2021 Jun 1;10:e65145.


About RBVI | Projects | People | Publications | Resources | Visit Us

Copyright 2018 Regents of the University of California. All rights reserved.