Structure and mechanism of the SGLT family of glucose transporters. Han L, Qu Q et al. Nature. 2022 Jan 13;601(7892):274–279.

Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex. Patil DN, Singh S et al. Science. 2022 Jan 7;375(6576):86-91.

Structure and plasticity of indoleamine 2,3-dioxygenase 1 (IDO1). Röhrig UF, Michielin O, Zoete V. J Med Chem. 2021 Dec 23;64(24):17690-17705.

Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2. Fukudome A, Singh J et al. Proc Natl Acad Sci USA. 2021 Dec 21;118(51):e2115899118.

The conformational cycle of prestin underlies outer-hair cell electromotility. Bavi N, Clark MD et al. Nature. 2021 Dec 16;600(7889):553–558.

Computed structures of core eukaryotic protein complexes. Humphreys IR, Pei J et al. Science. 2021 Dec 10;374(6573):eabm4805.

Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface. Diwanji D, Trenker R et al. Nature. 2021 Dec 9;600(7888):339–343.

Structure, function and pharmacology of human itch receptor complexes. Yang F, Guo L et al. Nature. 2021 Dec 2;600(7887):164–169.

The human microbiome encodes resistance to the antidiabetic drug acarbose. Balaich J, Estrella M et al. Nature. 2021 Dec 2;600(7887):110-115.

Molecular structure of an open human KATP channel. Zhao C, MacKinnon R. Proc Natl Acad Sci USA. 2021 Nov 30;118(48):e2112267118.

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. Meng Y, Davies KA et al. Nat Commun. 2021 Nov 22;12(1):6783.

A viral RNA hijacks host machinery using dynamic conformational changes of a tRNA-like structure. Bonilla SL, Sherlock ME et al. Science. 2021 Nov 19;374(6570):955-960.

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. de Almeida M, Hinterndorfer M et al. Nature. 2021 Nov 18;599(7885):491-496.

Dispatched uses Na+ flux to power release of lipid-modified Hedgehog. Wang Q, Asarnow DE et al. Nature. 2021 Nov 11;599(7884):320-324.

Kainate receptor modulation by NETO2. He L, Sun J et al. Nature. 2021 Nov 11;599(7884):325-329.

Mapping the catalytic conformations of an assembly-line polyketide synthase module. Cogan DP, Zhang K et al. Science. 2021 Nov 5;374(6568):729-734.

Bluetongue virus capsid protein VP5 perforates membranes at low endosomal pH during viral entry. Xia X, Wu W et al. Nat Microbiol. 2021 Nov;6(11):1424-1432.

The cellular environment shapes the nuclear pore complex architecture. Schuller AP, Wojtynek M et al. Nature. 2021 Oct 28;598(7882):667–671.

Pan-ebolavirus protective therapy by two multifunctional human antibodies. Gilchuk P, Murin CD et al. Cell. 2021 Oct 28;184(22):5593-5607.e18.

Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas. Hu C, Almendros C et al. Nature. 2021 Oct 21;598(7881):515-520.

Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA. Anso I, Basso LGM et al. Sci Adv. 2021 Oct 15;7(42):eabj4565.

Structural basis of human transcription-DNA repair coupling. Kokic G, Wagner FR et al. Nature. 2021 Oct 14;598(7880):368-372.

The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes. Tran NH, Carter SD et al. Science. 2021 Oct 1;374(6563):52-57.

A practical guide to large-scale docking. Bender BJ, Gahbauer S et al. Nat Protoc. 2021 Oct;16(10):4799-4832.

The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes. Sakuragi T, Kanai R et al. Nat Struct Mol Biol. 2021 Oct;28(10):825-834.

Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations. Abe K, Yamamoto K et al. Nat Commun. 2021 Sep 29;12(1):5709.

Structural insights into the inhibition of undecaprenyl pyrophosphate synthase from Gram-positive bacteria. Workman SD, Day J et al. J Med Chem. 2021 Sep 23;64(18):13540-13550.

Cryo-EM structure of the Rhodospirillum rubrum RC-LH1 complex at 2.5 Å. Qian P, Croll TI et al. Biochem J. 2021 Sep 17;478(17):3253-3263.

Structural basis of RNA polymerase inhibition by viral and host factors. Pilotto S, Fouqueau T et al. Nat Commun. 2021 Sep 17;12(1):5523.

Structure of Geobacter pili reveals secretory rather than nanowire behaviour. Gu Y, Srikanth V et al. Nature. 2021 Sep 16;597(7876):430-434.

In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli. Erdmann PS, Hou Z et al. Nat Commun. 2021 Sep 10;12(1):5364.

Broad betacoronavirus neutralization by a stem helix-specific human antibody. Pinto D, Sauer MM et al. Science. 2021 Sep 3;373(6559):1109-1116.

Evolving cryo-EM structural approaches for GPCR drug discovery. Zhang X, Johnson RM et al. Structure. 2021 Sep 2;29(9):963-974.e6.

Molecular mechanism of prestin electromotive signal amplification. Ge J, Elferich J et al. Cell. 2021 Sep 2;184(18):4669-4679.e13.

Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM. Sun M, Azumaya CM et al. J Struct Biol. 2021 Sep;213(3):107745.

Structural basis of RNA processing by human mitochondrial RNase P. Bhatta A, Dienemann C et al. Nat Struct Mol Biol. 2021 Sep;28(9):713-723.

Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. Su Z, Zhang K et al. Nature. 2021 Aug 26;596(7873):603-607.

Ankyrin repeats in context with human population variation. Utgés JS, Tsenkov MI et al. PLoS Comput Biol. 2021 Aug 24;17(8):e1009335.

Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Hu Q, Botuyan MV et al. Nature. 2021 Aug 19;596(7872):438-443.

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants. Yuan M, Huang D et al. Science. 2021 Aug 13;373(6556):eabh1139.

Chromosome modeling on downsampled Hi-C maps enhances the compartmentalization signal. Oliveira Junior AB, Estrada CP et al. J Phys Chem B. 2021 Aug 12;125(31):8757-8767.

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM. Antanasijevic A, Sewall LM et al. Nat Commun. 2021 Aug 10;12(1):4817.

Maturation of the matrix and viral membrane of HIV-1. Qu K, Ke Z et al. Science. 2021 Aug 6;373(6555):700-704.

Gold nanoparticles and tilt pairs to assess protein flexibility by cryo-electron microscopy. Jagota M, Townshend RJL et al. Ultramicroscopy. 2021 Aug;227:113302.

Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch. Dai L, Xu K et al. Nat Immunol. 2021 Aug;22(8):958-968.

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Yu Q, Ni D et al. Nat Commun. 2021 Jul 19;12(1):4376.

Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells. Zhang J, Wang H et al. Cell Discov. 2021 Jul 13;7(1):51.

PspA adopts an ESCRT-III-like fold and remodels bacterial membranes. Junglas B, Huber ST et al. Cell. 2021 Jul 8;184(14):3674-3688.e18.

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates. Galaz-Montoya JG, Shahmoradian SH et al. Commun Biol. 2021 Jul 8;4(1):849.

Structural basis of omega-3 fatty acid transport across the blood-brain barrier. Cater RJ, Chua GL et al. Nature. 2021 Jul 8;595(7866):315-319.

High-resolution crystal structures of transient intermediates in the phytochrome photocycle. Carrillo M, Pandey S et al. Structure. 2021 Jul 1;29(7):743-754.e4.

Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry. Felker D, Zhang H et al. Biophys Chem. 2021 Jul;274:106590.

Structures of G(i)-bound metabotropic glutamate receptors mGlu2 and mGlu4. Lin S, Han S et al. Nature. 2021 Jun 24;594(7864):583-588.

Structures of human mGlu2 and mGlu7 homo- and heterodimers. Du J, Wang D et al. Nature. 2021 Jun 24;594(7864):589-593.

IonoBiology: The functional dynamics of the intracellular metallome, with lessons from bacteria. Galera-Laporta L, Comerci CJ et al. Cell Syst. 2021 Jun 16;12(6):497-508.

Structures of the human Mediator and Mediator-bound preinitiation complex. Chen X, Yin X et al. Science. 2021 Jun 4;372(6546):eabg0635.

Structure of the merozoite surface protein 1 from Plasmodium falciparum. Dijkman PM, Marzluf T et al. Sci Adv. 2021 Jun 2;7(23):eabg0465.

Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer. Staquicini FI, Hajitou A et al. eLife. 2021 Jun 1;10:e65145.

Structural basis for broad coronavirus neutralization. Sauer MM, Tortorici MA et al. Nat Struct Mol Biol. 2021 Jun;28(6):478-486.

Control of distal lysine coordination in a monomeric hemoglobin: A role for heme peripheral interactions. Martinez Grundman JE, Julió Plana L et al. J Inorg Biochem. 2021 Jun;219:111437.

Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling. Israeli H, Degtjarik O et al. Science. 2021 May 21;372(6544):808-814.

Mechanosensitive channel YnaI has lipid-bound extended sensor paddles. Hu W, Wang Z, Zheng H. Commun Biol. 2021 May 20;4(1):602.

Structures of telomerase at several steps of telomere repeat synthesis. He Y, Wang Y et al. Nature. 2021 May 20;593(7859):454-459.

Structural basis of long-range to short-range synaptic transition in NHEJ. Chen S, Lee L et al. Nature. 2021 May 13;593(7858):294-298.

CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation. Brilot AF, Lyon AS et al. eLife. 2021 May 5;10:e65168.

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2. McCallum M, De Marco A et al. Cell. 2021 Apr 29;184(9):2332-2347.e16.

DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Hollingsworth LR, Sharif H et al. Nature. 2021 Apr 29;592(7856):778-783.

Protomer alignment modulates specificity of RNA substrate recognition by Ire1. Li W, Crotty K et al. eLife. 2021 Apr 27;10:e67425.

Structural basis of malaria RIFIN binding by LILRB1-containing antibodies. Chen Y, Xu K et al. Nature. 2021 Apr 22;592(7855):639-643.

CryoET structures of immature HIV Gag reveal six-helix bundle. Mendonça L, Sun D et al. Commun Biol. 2021 Apr 16;4(1):481.

The molecular basis for sarcomere organization in vertebrate skeletal muscle. Wang Z, Grange M et al. Cell. 2021 Apr 15;184(8):2135-2150.e13.

Structure and dynamics of the CGRP receptor in apo and peptide-bound forms. Josephs TM, Belousoff MJ et al. Science. 2021 Apr 9;372(6538):eabf7258.

Structure of TFIIK for phosphorylation of CTD of RNA polymerase II. van Eeuwen T, Li T et al. Sci Adv. 2021 Apr 7;7(15):eabd4420.

Structural basis of FANCD2 deubiquitination by USP1-UAF1. Rennie ML, Arkinson C et al. Nat Struct Mol Biol. 2021 Apr;28(4):356-364.

Oncohistone mutations enhance chromatin remodeling and alter cell fates. Bagert JD, Mitchener MM et al. Nat Chem Biol. 2021 Apr;17(4):403-411.

The effect of spike mutations on SARS-CoV-2 neutralization. Rees-Spear C, Muir L et al. Cell Rep. 2021 Mar 23;34(12):108890.

eIF2B conformation and assembly state regulate the integrated stress response. Schoof M, Boone M et al. eLife. 2021 Mar 10;10:e65703.

Structural insights into membrane remodeling by SNX1. Zhang Y, Pang X et al. Proc Natl Acad Sci USA. 2021 Mar 9;118(10):e2022614118.

Trans-synaptic assemblies link synaptic vesicles and neuroreceptors. Martinez-Sanchez A, Laugks U et al. Sci Adv. 2021 Mar 5;7(10):eabe6204.

Parallel molecular mechanisms for enzyme temperature adaptation. Pinney MM, Mokhtari DA et al. Science. 2021 Mar 5;371(6533):eaay2784.

Structure and inhibition mechanism of the human citrate transporter NaCT. Sauer DB, Song J et al. Nature. 2021 Mar 4;591(7848):157-161.

BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1. Witus SR, Burrell AL et al. Nat Struct Mol Biol. 2021 Mar;28(3):268-277.

Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Horn-Ghetko D, Krist DT et al. Nature. 2021 Feb 25;590(7847):671-676.

Cryo-EM structure of enteric adenovirus HAdV-F41 highlights structural variations among human adenoviruses. Pérez-Illana M, Martínez M et al. Sci Adv. 2021 Feb 24;7(9):eabd9421.

Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody. Rappazzo CG, Tse LV et al. Science. 2021 Feb 19;371(6531):823-829.

Visualization of the mechanosensitive ion channel MscS under membrane tension. Zhang Y, Daday C et al. Nature. 2021 Feb 18;590(7846):509-514.

Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. Li W, Tian W et al. Nature. 2021 Feb 18;590(7846):498-503.

Structure of a microtubule-bound axonemal dynein. Walton T, Wu H, Brown A. Nat Commun. 2021 Jan 20;12(1):477.

Immature HIV-1 assembles from Gag dimers leaving partial hexamers at lattice edges as potential substrates for proteolytic maturation. Tan A, Pak AJ et al. Proc Natl Acad Sci USA. 2021 Jan 19;118(3):e2020054118.

SARS-CoV-2 structural analysis of receptor binding domain new variants from United Kingdom and South Africa. Padilla-Sanchez V. Res Ideas Outcomes. 2021 Jan 15; 7:e62936.

Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81. Susa KJ, Rawson S et al. Science. 2021 Jan 15;371(6526):300-305.

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. Gadadhar S, Alvarez Viar G et al. Science. 2021 Jan 8;371(6525):eabd4914.

Serial cryoFIB/SEM reveals cytoarchitectural disruptions in Leigh syndrome patient cells. Zhu Y, Sun D et al. Structure. 2021 Jan 7;29(1):82-87.e3.

The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion. Oliver SL, Xing Y et al. PLoS Pathog. 2021 Jan 7;17(1):e1008961.

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM. Xu C, Wang Y et al. Sci Adv. 2021 Jan 1;7(1):eabe5575.

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Bracken CJ, Lim SA et al. Nat Chem Biol. 2021 Jan;17(1):113-121.

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Barnes CO, Jette CA et al. Nature. 2020 Dec 24;588(7839):682-687.

Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. Fäßler F, Dimchev G et al. Nat Commun. 2020 Dec 22;11(1):6437.

Structure of the shutdown state of myosin-2. Scarff CA, Carrington G et al. Nature. 2020 Dec 17;588(7838):515-520.

Structures and distributions of SARS-CoV-2 spike proteins on intact virions. Ke Z, Oton J et al. Nature. 2020 Dec 17;588(7838):498-502.