Ligand and G-protein selectivity in the κ-opioid receptor. Han J, Zhang J et al. Nature. 2023 May 11;617(7960):417-425.

MELD-Bracket ranks binding affinities of diverse sets of ligands. Parui S, Robertson JC et al. J Chem Inf Model. 2023 May 8;63(9):2857-2865.

Molecular basis of translation termination at noncanonical stop codons in human mitochondria. Saurer M, Leibundgut M et al. Science. 2023 May 5;380(6644):531-536.

Structural basis of BAM-mediated outer membrane β-barrel protein assembly. Shen C, Chang S et al. Nature. 2023 May 4;617(7959):85–193.

Lesion recognition by XPC, TFIIH and XPA in DNA excision repair. Kim J, Li CL et al. Nature. 2023 May 4;617(7959):170–175.

A structural basis for prion strain diversity. Manka SW, Wenborn A et al. Nat Chem Biol. 2023 May;19(5):607-613.

Csx28 is a membrane pore that enhances CRISPR-Cas13b-dependent antiphage defense. VanderWal AR, Park JU et al. Science. 2023 Apr 28;380(6643):410-415.

Structural basis for GSDMB pore formation and its targeting by IpaH7.8. Wang C, Shivcharan S et al. Nature. 2023 Apr 20;616(7957):590–597.

Structural basis of sensory receptor evolution in octopus. Allard CAH, Kang G et al. Nature. 2023 Apr 13;616(7956):373-377.

Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses. Shrock EL, Timms RT et al. Science. 2023 Apr 7;380(6640):eadc9498.

Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Mao C, Xiao P et al. Science. 2023 Apr 7;380(6640):eadd6220.

Norovirus MLKL-like protein initiates cell death to induce viral egress. Wang G, Zhang D et al. Nature. 2023 Apr 6;616(7955):152–158.

Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1. Hu X, Yang P et al. Nature. 2023 Apr 6;616(7955):190–198.

A sequence-based foldability score combined with AlphaFold2 predictions to disentangle the protein order/disorder continuum. Bruley A, Bitard-Feildel T et al. Proteins. 2023 Apr;91(4):466-484.

Integrative structural analysis of the type III secretion system needle complex from Shigella flexneri. Flacht L, Lunelli M et al. Protein Sci. 2023 Apr;32(4):e4595.

Immunoglobulin M perception by FcμR. Li Y, Shen H et al. Nature. 2023 Mar 30;615(7954):907–912.

Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity. Zhai Y, Chen L et al. Science. 2023 Mar 17;379(6637):eabg2482.

Structure of the human DICER-pre-miRNA complex in a dicing state. Lee YY, Lee H et al. Nature. 2023 Mar 9;615(7951):331–338.

Structure and function of Plasmodium actin II in the parasite mosquito stages. Lopez AJ, Andreadaki M et al. PLoS Pathog. 2023 Mar 6;19(3):e1011174.

Variable microtubule architecture in the malaria parasite. Ferreira JL, Pražák V et al. Nat Commun. 2023 Mar 3;14(1):1216.

Human PRPS1 filaments stabilize allosteric sites to regulate activity. Hvorecny KL, Hargett K et al. Nat Struct Mol Biol. 2023 Mar;30(3):391-402.

In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes. Chen Z, Greenan GA et al. Nat Struct Mol Biol. 2023 Mar;30(3):360-369.

How to compile different types of structural visualizations in one panel. Bu F, Kompaniiets D, Liu B. Trends Biochem Sci. 2023 Mar;48(3):303-304.

Structural basis for substrate selection by the SARS-CoV-2 replicase. Malone BF, Perry JK et al. Nature. 2023 Feb 23;614(7949):781–787.

Menin “reads” H3K79me2 mark in a nucleosomal context. Lin J, Wu Y et al. Science. 2023 Feb 17;379(6633):717-723.

Structural basis of Rho-dependent transcription termination. Molodtsov V, Wang C et al. Nature. 2023 Feb 9;614(7947):367–374.

Structural basis of V-ATPase VO region assembly by Vma12p, 21p, and 22p. Wang H, Bueler SA, Rubinstein JL. Proc Natl Acad Sci USA. 2023 Feb 7;120(6):e2217181120.

Principles of mitoribosomal small subunit assembly in eukaryotes. Harper NJ, Burnside C, Klinge S. Nature. 2023 Feb 2;614(7946):175–181.

Human DNA-dependent protein kinase activation mechanism. Liang S, Blundell TL. Nat Struct Mol Biol. 2023 Feb;30(2):140-147.

A molecular network of conserved factors keeps ribosomes dormant in the egg. Leesch F, Lorenzo-Orts L et al. Nature. 2023 Jan 26;613(7945):712-720.

Structural basis for intrinsic transcription termination. You L, Omollo EO et al. Nature. 2023 Jan 26;613(7945):783-789.

Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus. Alexander JAN, Worrall LJ et al. Nature. 2023 Jan 12;613(7943):375–382.

Structure of a volume-regulated heteromeric LRRC8A/C channel. Rutz S, Deneka D et al. Nat Struct Mol Biol. 2023 Jan;30(1):52-61.

Alignment of major-groove hydrogen bond arrays uncovers shared information between different DNA sequences that bind the same protein. Sedhom J, Kinser J, Solomon LA. NAR Genom Bioinform. 2022 Dec 31;4(4):lqac101.

Structural insights into the mechanism of the sodium/iodide symporter. Ravera S, Nicola JP et al. Nature. 2022 Dec 22;612(7941):795–801.

Structural basis for the assembly of the type V CRISPR-associated transposon complex. Schmitz M, Querques I et al. Cell. 2022 Dec 22;185(26):4999-5010.e17.

Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes. Fan C, Cohen AA et al. Immunity. 2022 Dec 13;55(12):2419-2435.e10.

A novel capsid protein network allows the characteristic internal membrane structure of Marseilleviridae giant viruses. Chihara A, Burton-Smith RN et al. Sci Rep. 2022 Dec 11;12(1):21428.

Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT. Gestaut D, Zhao Y et al. Cell. 2022 Dec 8;185(25):4770-4787.e20.

Molecular basis for selective activation of DREADD-based chemogenetics. Zhang S, Gumpper RH et al. Nature. 2022 Dec 8;612(7939):354–362.

Structural basis of tankyrase activation by polymerization. Pillay N, Mariotti L et al. Nature. 2022 Dec 1;612(7938):162–169.

Recognition of cyclic dinucleotides and folates by human SLC19A1. Zhang Q, Zhang X et al. Nature. 2022 Dec 1;612(7938):170–176.

Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates. Reiss EIMM, van Haaren MM et al. NPJ Vaccines. 2022 Nov 25;7(1):152.

Three-dimensional flagella structures from animals' closest unicellular relatives, the Choanoflagellates. Pinskey JM, Lagisetty A et al. eLife. 2022 Nov 17;11:e78133.

TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand. Lim CS, Jang YH et al. Nat Commun. 2022 Nov 12;13(1):6876.

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages. Park YJ, Pinto D et al. Science. 2022 Nov 11;378(6620):619-627.

Bending forces and nucleotide state jointly regulate F-actin structure. Reynolds MJ, Hachicho C et al. Nature. 2022 Nov 10;611(7935):380–386.

Bestrophin-2 and glutamine synthetase form a complex for glutamate release. Owji AP, Yu K et al. Nature. 2022 Nov 3;611(7934):180-187.

Cryo-EM structures of human m6A writer complexes. Su S, Li S et al. Cell Res. 2022 Nov;32(11):982-994.

Algorithmic design of 3D wireframe RNA polyhedra. Elonen A, Natarajan AK et al. ACS Nano. 2022 Oct 25;16(10):16608-16616.

Molecular structures reveal synergistic rescue of Δ508 CFTR by Trikafta modulators. Fiedorczuk K, Chen J. Science. 2022 Oct 21;378(6617):284-290.

Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity. Kaplan AL, Confair DN et al. Nature. 2022 Oct 20;610(7932):582-591.

Structure of a mitochondrial ribosome with fragmented rRNA in complex with membrane-targeting elements. Tobiasson V, Berzina I, Amunts A. Nat Commun. 2022 Oct 17;13(1):6132.

Evolution of increased complexity and specificity at the dawn of form I Rubiscos. Schulz L, Guo Z et al. Science. 2022 Oct 14;378(6616):155-160.

Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2. Yin Y, Zhang F et al. Science. 2022 Oct 14;378(6616):eadd1268.

Structures of +1 nucleosome-bound PIC-Mediator complex. Chen X, Wang X et al. Science. 2022 Oct 7;378(6615):62-68.

Structure of dynein-dynactin on microtubules shows tandem adaptor binding. Chaaban S, Carter AP. Nature. 2022 Oct 6;610(7930):212-216.

Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor. Fink EA, Xu J et al. Science. 2022 Sep 30;377(6614):eabn7065.

Craspase is a CRISPR RNA-guided, RNA-activated protease. Hu C, van Beljouw SPB et al. Science. 2022 Sep 16;377(6612):1278-1285.

Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT. Ehara H, Kujirai T et al. Science. 2022 Sep 9;377(6611):eabp9466.

Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Kwon JJ, Hajian B et al. Nature. 2022 Sep 8;609(7926):408-415.

Archaic chaperone-usher pili self-secrete into superelastic zigzag springs. Pakharukova N, Malmi H et al. Nature. 2022 Sep 8;609(7926):335-340.

Structure of Tetrahymena telomerase-bound CST with polymerase α-primase. He Y, Song H et al. Nature. 2022 Aug 25;608(7924):813-818.

In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM. Huang CY, Draczkowski P et al. Nat Commun. 2022 Aug 19;13(1):4877.

Cryo-EM structures of two human B cell receptor isotypes. Ma X, Zhu Y et al. Science. 2022 Aug 19;377(6608):880-885.

Intermediates in SARS-CoV-2 spike-mediated cell entry. Marcink TC, Kicmal T et al. Sci Adv. 2022 Aug 19;8(33):eabo3153.

Architecture and self-assembly of the jumbo bacteriophage nuclear shell. Laughlin TG, Deep A et al. Nature. 2022 Aug 11;608(7922):429-435.

Implementation of occupied and virtual Edmiston-Ruedenberg orbitals using Cholesky decomposed integrals. Folkestad SD, Matveeva R et al. J Chem Theory Comput. 2022 Aug 9;18(8):4733-4744.

Integrative genome modeling platform reveals essentiality of rare contact events in 3D genome organizations. Boninsegna L, Yildirim A et al. Nat Methods. 2022 Aug;19(8):938-949.

Membrane-anchored HDCR nanowires drive hydrogen-powered CO2 fixation. Dietrich HM, Righetto RD et al. Nature. 2022 Jul 28;607(7920):823-830.

Fusion protein strategies for cryo-EM study of G protein-coupled receptors. Zhang K, Wu H et al. Nat Commun. 2022 Jul 28;13(1):4366.

Characterizing and explaining the impact of disease-associated mutations in proteins without known structures or structural homologs. Sen N, Anishchenko I et al. Brief Bioinform. 2022 Jul 18;23(4):bbac187.

A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel. Feng P, Wu X et al. Nature. 2022 Jul 14;607(7918):374-380.

2.7 Å cryo-EM structure of ex vivo RML prion fibrils. Manka SW, Zhang W et al. Nat Commun. 2022 Jul 13;13(1):4004.

Cryo-EM structure of a type IV secretion system. Macé K, Vadakkepat AK et al. Nature. 2022 Jul 7;607(7917):191-196.

Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate. McCorvie TJ, Loria PM et al. Nat Struct Mol Biol. 2022 Jul;29(7):628-638.

Structural basis of sodium-dependent bile salt uptake into the liver. Goutam K, Ielasi FS et al. Nature. 2022 Jun 30;606(7916):1015-1020.

Structure of the bile acid transporter and HBV receptor NTCP. Asami J, Kimura KT et al. Nature. 2022 Jun 30;606(7916):1021-1026.

Structural basis of GABA reuptake inhibition. Motiwala Z, Aduri NG et al. Nature. 2022 Jun 23;606(7915):820-826.

Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon. Hilal T, Killam BY et al. Science. 2022 Jun 17;376(6599):1338-1343.

Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex. Zhu X, Huang G et al. Science. 2022 Jun 10;376(6598):eabl8280.

Architecture of the cytoplasmic face of the nuclear pore. Bley CJ, Nie S et al. Science. 2022 Jun 10;376(6598):eabm9129.

Architecture of the linker-scaffold in the nuclear pore. Petrovic S, Samanta D et al. Science. 2022 Jun 10;376(6598):eabm9798.

Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses. He WT, Musharrafieh R et al. Nat Immunol. 2022 Jun;23(6):960-970.

A feature-guided, focused 3D signal permutation method for subtomogram averaging. Peters JJ, Leitz J et al. J Struct Biol. 2022 Jun;214(2):107851.

Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes. Wang C, Hesketh EL et al. Nat Commun. 2022 May 25;13(1):2921.

Posttranslational modification of microtubules by the MATCAP detyrosinase. Landskron L, Bak J et al. Science. 2022 May 20;376(6595):eabn6020.

Opening of glutamate receptor channel to subconductance levels. Yelshanskaya MV, Patel DS et al. Nature. 2022 May 5;605(7908):172-178.

Novel fold of rotavirus glycan-binding domain predicted by AlphaFold2 and determined by X-ray crystallography. Hu L, Salmen W et al. Commun Biol. 2022 May 5;5(1):419.

Cryo-EM structure of an active central apparatus. Han L, Rao Q et al. Nat Struct Mol Biol. 2022 May;29(5):472-482.

Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition. Shaban NM, Yan R et al. Sci Adv. 2022 Apr 29;8(17):eabm2827.

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1. Qu X, Qiu N et al. Nature. 2022 Apr 28;604(7907):779–785.

Three-dimensional structure determination of protein complexes using matrix-landing mass spectrometry. Westphall MS, Lee KW et al. Nat Commun. 2022 Apr 27;13(1):2276.

Computational design of mechanically coupled axle-rotor protein assemblies. Courbet A, Hansen J et al. Science. 2022 Apr 22;376(6591):383-390.

Molecular basis of receptor binding and antibody neutralization of Omicron. Hong Q, Han W et al. Nature. 2022 Apr 21;604(7906):546–552.

Activation of STING by targeting a pocket in the transmembrane domain. Lu D, Shang G et al. Nature. 2022 Apr 21;604(7906):557–562.

Structure deformation and curvature sensing of PIEZO1 in lipid membranes. Yang X, Lin C et al. Nature. 2022 Apr 14;604(7905):377–383.

Structure, substrate recognition and initiation of hyaluronan synthase. Maloney FP, Kuklewicz J et al. Nature. 2022 Apr 7;604(7904):195–201.

Identification of functional substates of KRas during GTP hydrolysis with enhanced sampling simulations. Zeng J, Chen J et al. Phys Chem Chem Phys. 2022 Mar 30;24(13):7653-7665.