Research at the RBVI

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Research and development is a major activity at the RBVI. Our goal for core and collaborative research projects is to advance the frontiers of biomedical research while developing new applications of immediate use to scientists. Below are descriptions and links to our core research and development projects and various collaborative research projects.

Technological Research and Development Projects

Chimera, an Extensible Molecular Modeling System

Tools for Integrated Sequence/Structure Analysis

Structure-Function Linkage Database

Software for Interactive Analysis of Large Molecular Assemblies

Integrated Visualization and Analysis of Biological Context

Older Research Projects

Collaborative Research Projects

Integrating Chimera Into the NRAMM Automated Processing Pipeline

Correlative Light and Electron Microscopy: Visualization of molecular machines in their native cell and tissue context

Visualization of Biological Assemblies at Intermediate Resolution

CryoEM Studies of Viruses

Data Management at the RCSB-PDB

Electron Microscopy Databank

Three Dimensional Structure of Chromosomes

Protein Modeling by Satisfaction of Spatial Restraints

Structure-Based Inhibitor Discovery

Pharmacogenetics of Membrane Transporters

The International Genetrap Consortium

Deciphering Enzyme Specificity

Integration of Methods for Structural Analysis of Functional Sites: Active Site Profiling and Fuzzy Functional Forms

Foundations for Genomic Enzymology: Families, Superfamilies, and Suprafamilies

Dissemination of Bioinformatics Tools from Genentech

Collaborative Research Opportunities

One of the key missions of our Center is to provide collaborative research opportunities for solving a wide range of molecular visualization problems. (See Laboratory Overview.) Collaborative projects bring our expertise in developing computational and visualization tools together with the biomedical expertise of outside scientists. Such efforts can lead to joint publications. Although our resources are limited, we welcome inquiries from scientists interested in collaborating. Inquiries should be directed to Prof. Thomas Ferrin, Director. It would be helpful to include a synopsis of your proposed project in your e-mail.