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Featured Citations

CryoET of β-amyloid and tau within postmortem Alzheimer's disease brain. Gilbert MAG, Fatima N et al. Nature. 2024 Jul 25;631(8022):913–919.

Structure and topography of the synaptic V-ATPase-synaptophysin complex. Wang C, Jiang W et al. Nature. 2024 Jul 25;631(8022):899–904.

Multiscale photocatalytic proximity labeling reveals cell surface neighbors on and between cells. Lin Z, Schaefer K et al. Science. 2024 Jul 19;385(6706):eadl5763.

Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein. Birkholz N, Kamata K et al. Nature. 2024 Jul 18;631(8021):670-677.

Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Zhang Y, Lai Y et al. Nature. 2024 Jul 11;631(8020):409–414.

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News

August 1, 2024

Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable August 1, 3-6 pm PDT.

June 17-18, 2024

Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable June 17-18 PDT.

June 13, 2023

The ChimeraX 1.8 production release is available! See the change log for what's new.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325, Chan Zuckerberg Initiative grant EOSS4-0000000439, and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

simple lighting soft lighting

cryoEM Ambient Occlusion

A cryoelectron microscopy map of the 26S proteasome (EMD-4321) is shown at the author-recommended contour level in two different lighting modes: “simple” on the left and “soft” on the right. Soft lighting includes ambient lighting and shadowing (occlusion) and can be turned on with the command lighting soft or by clicking the Graphics icon .

For setup of the righthand image, see the command file ambient.cxc.

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Example Image

HIV-1 protease B-factor coloring

B-factor Coloring

Atomic B-factor values are read from PDB and mmCIF input files and assigned as attributes that can be shown with coloring and used in atom specification. This example shows B-factor variation within a structure of the HIV-1 protease bound to an inhibitor (PDB 4hvp). For complete image setup, including positioning, color key, and label, see the command file bfactor.cxc.

Additional color key examples can be found in tutorials: Coloring by Electrostatic Potential, Coloring by Sequence Conservation

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