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Featured Citations

Structural basis of catalytic activation in human splicing. Schmitzová J, Cretu C et al. Nature. 2023 May 25;617(7962):842-850.

Structural atlas of a human gut crassvirus. Bayfield OW, Shkoporov AN et al. Nature. 2023 May 11;617(7960):409-416.

mRNA decoding in human is kinetically and structurally distinct from bacteria. Holm M, Natchiar SK et al. Nature. 2023 May 4;617(7959):200–207.

Cryptochrome-Timeless structure reveals circadian clock timing mechanisms. Lin C, Feng S et al. Nature. 2023 May 4;617(7959):194–199.

De novo design of protein interactions with learned surface fingerprints. Gainza P, Wehrle S et al. Nature. 2023 May 4;617(7959):176-184.

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News

May 9, 2023

The ChimeraX 1.6.1 production release is available! See the change log for what's new.

April 29, 2023

The ChimeraX 1.6 release candidate is available – please try it and report any issues. See the change log for what's new.

December 21, 2022

The RBVI wishes you a safe and happy holiday season! See our 2022 card and the gallery of previous cards back to 1985.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325, Chan Zuckerberg Initiative grant EOSS4-0000000439, and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

Cartoon/Nucleotide Presets

The Presets menu includes a few different combinations of cartoon and nucleotide styles, shown here along with overall settings from the Publication preset plus lighting depthcue false. The style settings of cartoons and nucleotides can be controlled individually (and with many more possibilities than shown here) with cartoon style and nucleotides, respectively. See also: Toolbar nucleotides icons

6cmn ribbons/slabs 6cmn cylinders/stubs 6cmn licorice/ovals
ribbons/slabs cylinders/stubs licorice/ovals
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Example Image

CaM-CaMKI peptide

Calmodulin and Target Peptide

Calmodulin (CaM) acts as a calcium sensor. When its four Ca++ sites are fully occupied, it binds and modulates the activity of various downstream proteins, including CaM-dependent protein kinase I (CaMKI). Here, a complex between CaM and its target peptide from CaMKI (PDB 1mxe) is shown with cartoons, a transparent molecular surface, silhouette outlines, and light soft ambient occlusion. (If you prefer a less smudgy/rustic appearance, try using light gentle instead.) For image setup other than positioning, see the command file cam.cxc.

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