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Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Mercer JAM, DeCarlo SJ et al. Science. 2024 Mar 15;383(6688):eadk4422.

Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome. Bai R, Yuan M et al. Science. 2024 Mar 15;383(6688):1245-1252.

UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER. DaRosa PA, Penchev I et al. Nature. 2024 Mar 14;627(8003):445–452.

The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons. Makhlouf L, Peter JJ et al. Nature. 2024 Mar 14;627(8003):437–444.

Targeted protein degradation via intramolecular bivalent glues. Hsia O, Hinterndorfer M et al. Nature. 2024 Mar 7;627(8002):204–211.

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News

January 22, 2024

ChimeraX 1.7.1 is available, with fixes for a few miscellaneous bugs that were identified after the 1.7 release.

December 19, 2023

The ChimeraX 1.7 production release is available! See the change log for what's new. Future Mac releases will require macOS 11 or higher.

November 6, 2023

The ChimeraX 1.7 release candidate is available – please try it and report any issues. See the change log for what's new.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325, Chan Zuckerberg Initiative grant EOSS4-0000000439, and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

1g74 per-model clipping

Per-Model Clipping

Front/back (rotatable) clipping can be applied selectively to some models but not others. This is most often used to slice a molecular surface but not the corresponding atomic structure.

For example, the protein in PDB entry 1g74 has an oleic acid residue OLA in an interior pocket. The script in pmc.cxc shows the protein surface, activates front clipping for all models, and then turns it off for just the atomic model, as shown in the figure. The clipping plane can be translated and rotated interactively with the mouse .

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Example Image

The Human Ribosome

The architecture of the human ribosome has been determined at near-atomic resolution by electron microscopy (Anger et al., Nature 497:80 (2013)). The structure, comprising 82 proteins and five RNA molecules, is shown with shadows cast from all directions to accentuate depth. In the background are schematic representations of contacts between the component molecules.

See the image setup script card.cxc using the 'Tis the Season color palette (credit to MrsP). See also the RBVI holiday card gallery.

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