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Recent Citations

Structural insights into TRPM8 inhibition and desensitization. Diver MM, Cheng Y, Julius D. Science. 2019 Sep 27;365(6460):1434-1440.

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle. Brouwer PJM, Antanasijevic A et al. Nat Commun. 2019 Sep 19;10(1):4272.

Hydrophobic gasket mutation produces gating pore currents in closed human voltage-gated proton channels. Banh R, Cherny VV et al. Proc Natl Acad Sci USA. 2019 Sep 17;116(38):18951-18961.

Tuning metal-metal interactions through reversible ligand folding in a series of dinuclear iron complexes. Zhang S, Wang Q et al. Inorg Chem. 2019 Sep 16;58(18):12234-12244.

Structures of influenza A virus RNA polymerase offer insight into viral genome replication. Fan H, Walker AP et al. Nature. 2019 Sep 12;573(7773):287-290.

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News

September 21, 2019

A production release candidate (version 1.14) is available; please try it and report any problems. See the release notes for what's new.

November 17, 2018

Chimera production release 1.13.1 is now available; see the release notes for what's new. The Mac version requires OS 10.10 or later.

October 22, 2018

Mac users: the 1.13.1 release candidate and recent daily builds contain a fix for Mojave (OS 10.14). These versions require OS 10.10 or later.

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Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, nonprofit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), supported in part by the National Institutes of Health (P41-GM103311).

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the RBVI, following UCSF Chimera.

Feature Highlight

density display

Density Display

Electron density maps can be read from local files or fetched from databases. Chimera's Volume Viewer allows adjusting contour levels interactively, showing multiple isosurfaces for a given map, and restricting display to a zone around selected atoms. The figure shows PDB entry 2fma and its electron density map. Settings are similar to those described in the Density Display tutorial. See also: Chimera volume display guide

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Gallery Sample

Peroxiredoxin Wreath

Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.

See also the RBVI holiday card gallery.

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