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A μ-opioid receptor modulator that works cooperatively with naloxone. O'Brien ES, Rangari VA et al. Nature. 2024 Jul 18;631(8021):686–693.

Molecular mechanism of plasmid elimination by the DdmDE defense system. Loeff L, Adams DW et al. Science. 2024 Jul 12;385(6705):188-194.

Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Hu X, Ao W et al. Nature. 2024 Jul 11;631(8020):459–466.

Evolution and host-specific adaptation of Pseudomonas aeruginosa. Weimann A, Dinan AM et al. Science. 2024 Jul 5;385(6704):eadi0908.

Electric nuclear quadrupole coupling reveals dissociation of HCl with a few water molecules. Xie F, Tikhonov DS, Schnell M. Science. 2024 Jun 28;384(6703):1435-1440.

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News

July 16, 2024

Chimera production release 1.18 is now available. See the release notes for details.

June 17-18, 2024

Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable June 17-18 PDT.

October 30-31, 2023

Planned downtime: The Chimera and ChimeraX websites and associated web services will be unavailable Oct 30 8am PDT – Oct 31 11:59pm PDT.

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Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

2mnr metal site
2mnr metal site

Metal Geometry

The Metal Geometry tool facilitates analysis of metal-binding sites. It lists potential metal-coordinating atoms (nearby nucleophilic heteroatoms) and suggests likely coordination geometries. An idealized geometry can be depicted with solid arrows, as shown in the figure for the octahedral coordination of Mn++ by six atoms, and the coordination pseudobonds in the structure can be updated to match the chosen geometry.

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Gallery Sample

Peroxiredoxin Wreath

Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.

See also the RBVI holiday card gallery.

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