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Recent Citations

Molecular architecture of the inner ring scaffold of the human nuclear pore complex. Kosinski J, Mosalaganti S et al. Science. 2016 Apr 15;352(6283):363-5.

Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Louder RK, He Y et al. Nature. 2016 Mar 31;531(7596):604-9.

Electronic structure of a CuII-alkoxide complex modeling intermediates in copper-catalyzed alcohol oxidations. Hayes EC, Porter TR et al. J Am Chem Soc. 2016 Mar 30;138(12):4132-45.

Force-producing ADP state of myosin bound to actin. Wulf SF, Ropars V et al. Proc Natl Acad Sci USA. 2016 Mar 29;113(13):E1844-52.

Improving functional annotation in the DRE-TIM metallolyase superfamily through identification of active site fingerprints. Kumar G, Johnson JL, Frantom PA. Biochemistry. 2016 Mar 29;55(12):1863-72.

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Chimera Search

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April 6, 2016

A production release candidate (v1.11) is available; please try it and report any problems. 64-bit builds are now recommended for all capable platforms, and v1.11 will be the last to support 32-bit builds. See the release notes for what's new.

July 23, 2015

Chimera production release 1.10.2 is now available. Fixes include code signing for Mac OS X installation. The 1.10 series will be the last to support OS X 10.6 and 10.7. See the release notes for details.

January 9, 2015

Chimera production release 1.10.1 is now available. 64-bit builds are recommended for all capable platforms, and the 1.10 series will be the last to support OS X 10.6 and 10.7. See the release notes for details.

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Upcoming Events

UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, non-profit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), funded by the National Institutes of Health (NIGMS P41-GM103311).

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the RBVI, following UCSF Chimera. It is in early development and not yet publicly released, with release anticipated sometime in 2016.

Feature Highlight

5 comparative models
Model List dialog

Chimera Interface to Modeller

Chimera provides a graphical interface to running the program Modeller, either locally or via a web service hosted by the UCSF RBVI. Two types of calculations are available:

  • Comparative (homology) modeling. Theoretical models of a protein target are generated using at least one known related template structure and a target-template sequence alignment. There are several ways to generate these inputs in Chimera. See also the Comparative Modeling tutorial.

  • Building parts of a protein without using a template. Missing segments can be built de novo, or existing segments refined by generating additional possible conformations.
Modeller is developed by the Sali Lab.

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Gallery Sample

Orexin Receptor Complex

The image shows the structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant, Protein Data Bank entry 4s0v. The drug is shown as spheres colored by element, and the receptor as ribbons with secondary structure elements rainbow-colored from blue at the N-terminus to red at the C-terminus. (More samples...)