Structural basis of Gs and Gi recognition by the human glucagon receptor. Qiao A, Han S et al. Science. 2020 Mar 20;367(6484):1346-1352.
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Wrapp D, Wang N et al. Science. 2020 Mar 13;367(6483):1260-1263.
Gene expression and cell identity controlled by anaphase-promoting complex. Oh E, Mark KG et al. Nature. 2020 Mar 5;579(7797):136-140.
Structural basis of ligand recognition and self-activation of orphan GPR52. Lin X, Li M et al. Nature. 2020 Mar 5;579(7797):152-157.
Measurement of atom resolvability in cryo-EM maps with Q-scores. Pintilie G, Zhang K et al. Nat Methods. 2020 Mar;17(3):328-334.(Previously featured citations...)
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UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, nonprofit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics (RBVI), supported in part by the National Institutes of Health (P41-GM103311).
UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the RBVI, following UCSF Chimera.
Space Navigator is an inexpensive ($60) USB input device from 3Dconnexion for moving and rotating models in 3 dimensions. This animation (8 Mb) shows docking a phage enzyme (PDB 1v0e) into an electron microscopy map (EMDB 1333) using a space navigator and mouse. Works with Windows and Mac Chimera versions (details).(More features...)
Mutations that inactivate the tumor suppressor p53 are found in over 50% of human cancers, and most of the cancer-associated mutations are within its DNA-binding domain. The image shows a tetramer of the p53 DNA-binding domain complexed with DNA (Protein Data Bank entry 2ac0). The tetramer subunits are shown as light blue, green, orange, and yellow ribbons, with red spheres marking several major "hot spots" of mutation. The DNA is shown in purple and blue. (More samples...)
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