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Recent Citations
Molecular architecture of a eukaryotic translational initiation complex. Fernández IS, Bai XC et al. Science. 2013 Nov 15;342(6160):1240585.
Cross-talk between the ligand- and DNA-binding domains of estrogen receptor. Huang W, Greene GL et al. Proteins. 2013 Nov;81(11):1900-9.
ATP-driven molecular chaperone machines. Clare DK, Saibil HR. Biopolymers. 2013 Nov;99(11):846-59.
Discovery of new enzymes and metabolic pathways by using structure and genome context. Zhao S, Kumar R et al. Nature. 2013 Oct 31;502(7473):698-702.
A radical intermediate in tyrosine scission to the CO and CN– ligands of FeFe hydrogenase. Kuchenreuther JM, Myers WK et al. Science. 2013 Oct 25;342(6157):472-5.
(Previously featured citations...)Chimera Search
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October 31, 2013
Chimera production release 1.8.1 is now available. Changes since 1.8 are mainly to fix problems with Mac OS X 10.9 (Mavericks). See the release notes for further details and for a list of new features since the 1.7 release.
June 7, 2013
Chimera production release 1.8 is now available. See the release notes for new features since the 1.7 release.
April 18, 2013
A production release candidate (version 1.8) is now available; please try it and report any problems. See the release notes for changes relative to the previous release.
(Previous news...)Upcoming Events
UCSF Chimera is a highly extensible program for interactive visualization and analysis of molecular structures and related data, including density maps, supramolecular assemblies, sequence alignments, docking results, trajectories, and conformational ensembles. High-quality images and animations can be generated. Chimera includes complete documentation and several tutorials, and can be downloaded free of charge for academic, government, non-profit, and personal use. Chimera is developed by the Resource for Biocomputing, Visualization, and Informatics, funded by the National Institutes of Health (NIGMS P41-GM103311).
Feature Highlight
The ConSurf Server provides results as Chimera Web data; after browser configuration, a single click displays the color-coded query structure and multiple sequence alignment with phylogenetic tree and custom headers in a locally installed copy of Chimera (details).
Special thanks to Elana Erez and the Ben-Tal and Pupko groups at Tel Aviv University, and to Fabian Glaser at the Technion.
(More features...)Gallery Sample
Thermosomes are hollow balls inside which proteins are folded. They are found in the cytosol of eukaryotes and in archaea. Eukaryotic thermosomes have 8 different protein subunits, while archaeal ones are composed of one, two or three different proteins. The one shown from Thermoplasma acidophilum has two distinct proteins colored blue and yellow, each present in 8 copies. The two proteins have 60% sequence identity and are very similar in structure. One monomer is shown as a ribbon. Actin and tubulin are folded by eukaryotic thermosomes.
Protein Data Bank model 1a6d.
(More samples...)