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Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity. Zhai Y, Chen L et al. Science. 2023 Mar 17;379(6637):eabg2482.

Structure of the human DICER-pre-miRNA complex in a dicing state. Lee YY, Lee H et al. Nature. 2023 Mar 9;615(7951):331–338.

Structural basis for substrate selection by the SARS-CoV-2 replicase. Malone BF, Perry JK et al. Nature. 2023 Feb 23;614(7949):781–787.

Menin “reads” H3K79me2 mark in a nucleosomal context. Lin J, Wu Y et al. Science. 2023 Feb 17;379(6633):717-723.

Structural basis of Rho-dependent transcription termination. Molodtsov V, Wang C et al. Nature. 2023 Feb 9;614(7947):367–374.

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December 21, 2022

The RBVI wishes you a safe and happy holiday season! See our 2022 card and the gallery of previous cards back to 1985.

September 27, 2022

Website downtime: The RBVI website (Chimera, ChimeraX, etc.) and RBVI-hosted web services will be down for maintenance from Tue, Sep 27 9pm PDT, through Wed, possibly extending to Thu, Sep 29 5pm PDT.

December 20, 2021

The RBVI wishes you a safe and happy holiday season! See our 2021 card and the gallery of previous cards back to 1985.

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Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features. ChimeraX includes a significant subset of Chimera features (with more to come, see the missing features list) and is under active development. Users may choose to use both programs, and it is fine to have both installed.

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

pipes & planks

Pipes and Planks

The PipesAndPlanks tool shows protein helices as “pipes” (cylinders) and strands as “planks” (rectangular boxes), with connectors for the intervening coil. Adjustable settings include pipe radius, plank width, colors, and whether to include arrowheads to show chain N→C directionality (see image how-to).

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Gallery Sample


Thermosomes are hollow balls inside which proteins are folded. They are found in the cytosol of eukaryotes and in archaea. Eukaryotic thermosomes have 8 different protein subunits, while archaeal ones are composed of one, two or three different proteins. The one shown from Thermoplasma acidophilum has two distinct proteins colored blue and yellow, each present in 8 copies. The two proteins have 60% sequence identity and are very similar in structure. One monomer is shown as a ribbon. Actin and tubulin are folded by eukaryotic thermosomes.

Protein Data Bank model 1a6d.

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