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Recent Citations

Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody. Rappazzo CG, Tse LV et al. Science. 2021 Feb 19;371(6531):823-829.

Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. Li W, Tian W et al. Nature. 2021 Feb 18;590(7846):498-503.

Structure of a microtubule-bound axonemal dynein. Walton T, Wu H, Brown A. Nat Commun. 2021 Jan 20;12(1):477.

Immature HIV-1 assembles from Gag dimers leaving partial hexamers at lattice edges as potential substrates for proteolytic maturation. Tan A, Pak AJ et al. Proc Natl Acad Sci USA. 2021 Jan 19;118(3):e2020054118.

Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81. Susa KJ, Rawson S et al. Science. 2021 Jan 15;371(6526):300-305.

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News

December 18, 2020

Chimera production release 1.15 is now available. See the release notes for what's new.

December 11, 2020

The RBVI wishes you a safe and happy holiday season! See our 2020 card and the gallery of previous cards back to 1985.

November 4, 2020

A 1.15 production release candidate is available, including a fix to work with the new PDB fetch locations (see the release notes). Please try it and report any problems.

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Upcoming Events

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features. ChimeraX includes a significant subset of Chimera features (with more to come, see the missing features list) and is under active development. Users may choose to use both programs, and it is fine to have both installed.

Chimera is no longer under active development, and is only updated for critical maintenance. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

Space Navigator demonstration

Space Navigator Input Device

Space Navigator is an inexpensive ($60) USB input device from 3Dconnexion for moving and rotating models in 3 dimensions. This animation (8 Mb) shows docking a phage enzyme (PDB 1v0e) into an electron microscopy map (EMDB 1333) using a space navigator and mouse. Works with Windows and Mac Chimera versions (details).

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Gallery Sample

RNA Bases

Large ribosomal RNA is shown with individual bases depicted using solvent excluded molecular surfaces. Bases A, C, G, U are colored red, yellow, green, and blue. The surfaces were made with the Chimera multiscale tool in combination with the nucleic acid blobs plug-in. The image was raytraced using POVray.

Protein Data Bank model 1s72.

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