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DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Hollingsworth LR, Sharif H et al. Nature. 2021 Apr 29;592(7856):778-783.
Structural basis of malaria RIFIN binding by LILRB1-containing antibodies. Chen Y, Xu K et al. Nature. 2021 Apr 22;592(7855):639-643.
Structure and dynamics of the CGRP receptor in apo and peptide-bound forms. Josephs TM, Belousoff MJ et al. Science. 2021 Apr 9;372(6538):eabf7258.
Structure of TFIIK for phosphorylation of CTD of RNA polymerase II. van Eeuwen T, Li T et al. Sci Adv. 2021 Apr 7;7(15):eabd4420.
Structural basis of FANCD2 deubiquitination by USP1-UAF1. Rennie ML, Arkinson C et al. Nat Struct Mol Biol. 2021 Apr;28(4):356-364.
(Previously featured citations...)Chimera Search
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December 18, 2020
Chimera production release 1.15 is now available. See the release notes for what's new.
December 11, 2020
|
November 4, 2020
A 1.15 production release candidate is available, including a fix to work with the new PDB fetch locations (see the release notes). Please try it and report any problems.
(Previous news...)Upcoming Events
UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.
We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features. ChimeraX includes a significant subset of Chimera features (with more to come, see the missing features list) and is under active development. Users may choose to use both programs, and it is fine to have both installed.
Chimera is no longer under active development, and is only updated for critical maintenance. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.
Feature Highlight
There are several ways to superimpose structures in Chimera:
•
MatchMaker performs a fit after automatically identifying
which residues should be paired.
Pairing uses both sequence and secondary structure,
allowing similar structures to be superimposed even when
their sequence similarity is low to undetectable.
The figure shows five distantly related proteins
(pairwise sequence identities <25%) from the
SCOP WD40 superfamily before and after
MatchMaker superposition with default parameters.
•
Structures can be matched
using a pre-existing sequence alignment.
•
The exact atoms to pair can be specified with the
match command.
This works on any type of structure, while the preceding methods
apply only to peptide and nucleotide chains.
•
Structures can be superimposed manually by
activating/deactivating them for motion and
using the mouse.
Gallery Sample
Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.
See also the RBVI holiday card gallery.
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