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Recent Citations

Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81. Susa KJ, Rawson S et al. Science. 2021 Jan 15;371(6526):300-305.

SARS-CoV-2 structural analysis of receptor binding domain new variants from United Kingdom and South Africa. Padilla-Sanchez V. Res Ideas Outcomes. 2021 Jan 15; 7:e62936.

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. Gadadhar S, Alvarez Viar G et al. Science. 2021 Jan 8;371(6525):eabd4914.

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Bracken CJ, Lim SA et al. Nat Chem Biol. 2021 Jan;17(1):113-121.

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Barnes CO, Jette CA et al. Nature. 2020 Dec 24;588(7839):682-687.

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News

December 18, 2020

Chimera production release 1.15 is now available. See the release notes for what's new.

December 11, 2020

The RBVI wishes you a safe and happy holiday season! See our 2020 card and the gallery of previous cards back to 1985.

November 4, 2020

A 1.15 production release candidate is available, including a fix to work with the new PDB fetch locations (see the release notes). Please try it and report any problems.

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Upcoming Events

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. High-quality images and animations can be generated. Chimera includes complete documentation and is free of charge for academic, government, nonprofit, and personal use. Commercial users, please see Chimera commercial licensing.

Chimera development was supported by the National Institutes of Health (P41-GM103311).

UCSF ChimeraX is the next-generation molecular visualization program from the RBVI, following UCSF Chimera. We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages. ChimeraX replaces a significant subset of Chimera features, includes several completely new features, and is under active development. Users may certainly choose to use both programs, and it is fine to have both installed.

Feature Highlight

Multiscale Models

Multiscale Models

The Multiscale Models extension allows Chimera to display large complexes such as virus capsids, ribosomes, and chromatin. It displays the quaternary structure of PDB models and allows subunits to be selected and shown in atomic detail. Matrices are read from PDB files that specify the biological unit. Crystallographic packing can also be shown.

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Gallery Sample

Wasabi Receptor

The image shows the structure of the human TRPA1 ion channel (wasabi receptor) determined by electron cryo-microscopy, Protein Data Bank entry 3j9p. The four subunits of the tetramer are shown as ribbons in different colors over a dark-to-light gradient background. (More samples...)


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