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Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability. Brouwer PJM, Caniels TG et al. Science. 2020 Aug 7;369(6504):643-650.

Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane. Yin J, Chen KM et al. Nature. 2020 Aug 6;584(7819):125–129.

Structure of replicating SARS-CoV-2 polymerase. Hillen HS, Kokic G et al. Nature. 2020 Aug 6;584(7819):154-156.

Mycobacterial and human nitrobindins: structure and function. De Simone G, di Masi A et al. Antioxid Redox Signal. 2020 Aug 1;33(4):229-246.

DNA capture by a CRISPR-Cas9-guided adenine base editor. Lapinaite A, Knott GJ et al. Science. 2020 Jul 31;369(6503):566-571.

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News

November 13, 2019

Chimera production release 1.14 is now available. See the release notes for what's new.

September 21, 2019

A production release candidate (version 1.14) is available; please try it and report any problems. See the release notes for what's new.

November 17, 2018

Chimera production release 1.13.1 is now available; see the release notes for what's new. The Mac version requires OS 10.10 or later.

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Upcoming Events

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. High-quality images and animations can be generated. Chimera includes complete documentation and is free of charge for academic, government, nonprofit, and personal use. Chimera development was supported by the National Institutes of Health (P41-GM103311).

UCSF ChimeraX is the next-generation molecular visualization program from the RBVI, following UCSF Chimera. We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages. ChimeraX replaces a significant subset of Chimera features, includes several completely new features, and is under active development. Users may certainly choose to use both programs, and it is fine to have both installed.

Feature Highlight

radial surface color

Radial Coloring

A surface can be colored radially, that is, by distance from a user-specified point. Additional options include coloring by distance from an axis or a plane. Different coloring schemes can be applied.

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Gallery Sample

Cavity and Tunnel Detection

Side-by-side views of a potassium channel structure (Protein Data Bank entry 1bl8) showing different approaches to cavity detection. On the left are molecular surface patches corresponding to the structure's two largest pockets by MS volume in the Computed Atlas of Surface Topography of proteins (CASTp) database. On the right is a tunnel in blue identified by the MolAxis server. Simple editing converted MolAxis output into a BILD file for display in Chimera. (More samples...)


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