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Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism. Noddings CM, Wang RY et al. Nature. 2022 Jan 20;601(7893):465-469.

Cryo-EM structures of amyloid-β 42 filaments from human brains. Yang Y, Arseni D et al. Science. 2022 Jan 14;375(6577):167-172.

Structural basis of branch site recognition by the human spliceosome. Tholen J, Razew M et al. Science. 2022 Jan 7;375(6576):50-57.

Structure of pathological TDP-43 filaments from ALS with FTLD. Arseni D, Hasegawa M et al. Nature. 2022 Jan 6;601(7891):139–143.

Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants. McCallum M, Walls AC et al. Science. 2021 Dec 24;374(6575):1621-1626.

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News

December 8, 2021

The ChimeraX 1.3 production release is available. See the change log for what's new.

October 22, 2021

The ChimeraX 1.3 release candidate is available. Please try it and report any issues. See the change log for what's new.

May 28, 2021

The ChimeraX 1.2 production release is available. See the change log for what's new.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325 and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

Elp2 fit into map of Elongator subcomplex

Fitting to Density Maps

Atomic structures and/or maps can be fit rigidly into other maps with the Map icon , the Fit in Map tool, or the fitmap command. A common use is to locally optimize the fit after initial placement by hand. The command includes options for symmetrical and sequential fitting, as well as global search to generate multiple starting points for local optimization.

Elongator is a highly conserved complex that associates with RNA polymerase II during transcriptional elongation. In the image, one of its six subunits, Elp2 (PDB 5m2n), has been fit into a map of the Elp123 subcomplex (EMDB 4151).

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Example Image

HIV-1 protease B-factor coloring

B-factor Coloring

Atomic B-factor values are read from PDB and mmCIF input files and assigned as attributes that can be shown with coloring and used in atom specification. This example shows B-factor variation within a structure of the HIV-1 protease bound to an inhibitor (PDB 4hvp). For complete image setup, including positioning, color key, and label, see the command file bfactor.cxc.

Additional color key examples can be found in tutorials: Coloring by Electrostatic Potential, Coloring by Sequence Conservation

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