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Featured Citations

An ATP-gated molecular switch orchestrates human mRNA export. Hohmann U, Graf M et al. Nature. 2026 Jan 22;649(8098):1042–1050.

ZAK activation at the collided ribosome. Huso VL, Niu S et al. Nature. 2026 Jan 22;649(8098):1051–1060.

Semantic design of functional de novo genes from a genomic language model. Merchant AT, King SH et al. Nature. 2026 Jan 15;649(8097):749-758.

Structural basis of regulated N-glycosylation at the secretory translocon. Yamsek M, Ma M et al. Nature. 2026 Jan 15;649(8097):777–784.

Top-down scoring of spectral fitness by image analysis for protein structure validation. Harding BD, DeZonia B et al. J Chem Inf Model. 2026 Jan 12;66(1):567-576.

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News

December 25, 2025

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The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

December 16, 2025

The ChimeraX 1.11 production release is available! See the change log for what's new.

November 21, 2025

The ChimeraX 1.11 release candidate is available – please try it and report any issues. See the change log for what's new. This will be the last release to support Red Hat Enterprise Linux 8 and its derivatives.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

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Stylized Nucleotides

Different representations of nucleotides can be shown with the nucleotides command or Toolbar icons. Options include filled rings, slabs for bases (box, muffler, or ellipsoid shape), bumps on slabs to show base orientation, simple tubes instead of ribose atoms, and continuous or broken ladder rungs. Nucleotide representations can be the same color as the ribbon or a different color, and multiple nucleotide styles can be used within a single structure.

See also: Presets menu

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Example Image

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The Human Ribosome

The architecture of the human ribosome has been determined at near-atomic resolution by electron microscopy (Anger et al., Nature 497:80 (2013)). The structure, comprising 82 proteins and five RNA molecules, is shown with shadows cast from all directions to accentuate depth. In the background are schematic representations of contacts between the component molecules.

See the image setup script card.cxc using the 'Tis the Season color palette (credit to MrsP). See also the RBVI holiday card gallery.

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