Protein denaturation at the air-water interface and how to prevent it. D'Imprima E, Floris D et al. eLife. 2019 Apr 1;8. pii: e42747.
Structural snapshots of 26S proteasome reveal tetraubiquitin-induced conformations. Ding Z, Xu C et al. Mol Cell. 2019 Mar 21;73(6):1150-1161.e6.
Unexpected receptor functional mimicry elucidates activation of coronavirus fusion. Walls AC, Xiong X et al. Cell. 2019 Feb 21;176(5):1026-1039.e15.
Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Kalienkova V, Clerico Mosina V et al. eLife. 2019 Feb 21;8. pii: e44364.
Structure of a bacterial ATP synthase. Guo H, Suzuki T, Rubinstein JL. eLife. 2019 Feb 6;8. pii: e43128.See also: RCSB PDB Images
December 17, 2018
August 7, 2018
July 13, 2018
New Virtual Reality at UCSF website shares information on VR projects, resources, and related issues.Previous news...
April 18, 2019
Tom Goddard will be giving a ChimeraX tutorial on 3D microscopy visualization at the UCSF Parnassus Campus, Medical Sciences S-163, 12:30-3:30 pm.
UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see licensing.
ChimeraX development is supported in part by grants from the National Institutes of Health (currently R01-GM129325, previously P41-GM103311).
Multimeric assemblies defined in a structure's mmCIF file are automatically listed when the file is opened and can be reconstituted with the sym command. The complex of selenocysteine synthase and tRNASec (PDB 3w1k) is shown as molecular surfaces of different colors for different chains. The asymmetric unit is on the left and the assembly specified in the mmCIF file is on the right, with arrow and text annotations from 2dlabels. See the command file sym.cxc.More features...
KCNQ1 is the pore-forming subunit of a cardiac potassium channel. It binds to calmodulin, and mutations in either of these proteins can cause congenital long QT syndrome, a dangerous propensity for irregular heartbeats. In the image, a structure of the KCNQ1/calmodulin complex (PDB 5vms) has been assembled into the native tetrameric form with the sym command. The view is from the cytoplasmic side, with KCNQ1 shown as surfaces, calmodulin as cartoons, and calcium ions as balls. A pastel palette from ColorBrewer has been used to color the surfaces, darkened with color modify for the cartoons, and “rotated” 45° in hue for the ions. See the command file colormod.cxc.
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