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Structure of the ATP-driven methyl-coenzyme M reductase activation complex. Ramírez-Amador F, Paul S et al. Nature. 2025 Jun 19;642(8068):814–821.
Lewy-MSA hybrid fold drives distinct neuronal α-synuclein pathology. Enomoto M, Martinez-Valbuena I et al. Commun Biol. 2025 Jun 16;8(1):929.
Small molecules restore mutant mitochondrial DNA polymerase activity. Valenzuela S, Zhu X et al. Nature. 2025 Jun 12;642(8067):501–507.
PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease. Nyame K, Xiong J et al. Nature. 2025 Jun 12;642(8067):474–483.
Complex water networks visualized by cryogenic electron microscopy of RNA. Kretsch RC, Li S et al. Nature. 2025 Jun 5;642(8066):250–259.
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June 26, 2025
The ChimeraX 1.10 production release is available! See the change log for what's new.
May 7, 2025
The ChimeraX 1.10 release candidate is available – please try it and report any issues. See the change log for what's new.
March 19, 2025
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UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325.
Feature Highlight
3D images and time series from multichannel optical microscopy are shown in the
Volume Viewer
tool, with easy access to hiding/showing individual channels, changing
their colors, and adjusting threshold levels with the mouse. The menu of
style options includes “volume” (translucent blobs, as in the image),
surface, mesh, maximum intensity projection, single plane, and orthoplanes.
For convenience, the step size, region bounds, and display style of
different channels of the same dataset are coupled, in that changing
the setting of one channel automatically changes it for the others.
The image shows human induced pluripotent stem cells,
with plasma membrane in violet red, EGFP-tagged fibrillarin
(as a marker for nucleolus) in yellow, and DNA (nucleus) in turquoise.
The data are publicly available from the
Allen
Cell Explorer website, dataset: AICS-14_0.
Example Image
Atomic B-factor values are read from PDB and mmCIF input files
and assigned as attributes
that can be shown with
coloring
and used in
atom specification.
This example shows B-factor variation within a structure of the
HIV-1 protease bound to an inhibitor
(PDB 4hvp).
For complete image setup, including positioning,
color key, and label,
see the command file bfactor.cxc.
Additional color key examples can be found in tutorials:
Coloring by
Electrostatic Potential,
Coloring by Sequence Conservation
Multichannel Light Microscopy
B-factor Coloring
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