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Featured Citations

Quantum spin resonance in engineered proteins for multimodal sensing. Abrahams G, Štuhec A et al. Nature. 2026 Jan 29;649(8099):1172–1179.

RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity. Dmytrenko O, Yuan B et al. Nature. 2026 Jan 29;649(8099):1312–1321.

An ATP-gated molecular switch orchestrates human mRNA export. Hohmann U, Graf M et al. Nature. 2026 Jan 22;649(8098):1042–1050.

ZAK activation at the collided ribosome. Huso VL, Niu S et al. Nature. 2026 Jan 22;649(8098):1051–1060.

Semantic design of functional de novo genes from a genomic language model. Merchant AT, King SH et al. Nature. 2026 Jan 15;649(8097):749-758.

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News

December 25, 2025

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The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

December 16, 2025

The ChimeraX 1.11 production release is available! See the change log for what's new.

November 21, 2025

The ChimeraX 1.11 release candidate is available – please try it and report any issues. See the change log for what's new. This will be the last release to support Red Hat Enterprise Linux 8 and its derivatives.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

DNA/protein complex with struts

Struts for 3D Printing

Structures can be reinforced for 3D printing with pseudobonds. In this DNA-transcription factor complex (PDB 5ego), proteins are shown as ribbons and the DNA as a molecular surface. The pseudobonds in blue were read in from a manually created file, 5ego.pb, and further reinforcements in light gray were added automatically with the struts command. For image setup other than orientation, see the command file struts.cxc.

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Example Image

transducin switch regions

G-Protein Switch Regions

The GDP- and GTP-bound conformations of the transducin α-subunit (1tag and 1tnd, respectively) differ primarily in three regions, termed switch 1, switch 2, and switch 3. The structures have been superimposed with matchmaker and shown as cartoons, with “empty” outlines where the structures are almost the same (for simplicity, only one conformation's outlines are shown). The GTP analog GTPγS is displayed as spheres color-coded by heteroatom. For 2D labels and image setup other than structure orientation, see the command file switch.cxc.

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