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Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Burn GL, Raisch T et al. Nature. 2025 Nov 20;647(8090):747-756.
Sex and smoking bias in the selection of somatic mutations in human bladder. Calvet F, Blanco Martinez-Illescas R et al. Nature. 2025 Nov 13;647(8089):436-444.
A new paradigm for outer membrane protein biogenesis in the Bacteroidota. Liu X, Orenday Tapia L et al. Nature. 2025 Nov 13;647(8089):479–487.
Structural basis for mTORC1 activation on the lysosomal membrane. Cui Z, Esposito A et al. Nature. 2025 Nov 13;647(8089):536–543.
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex. Li C, Sun XN et al. Science. 2025 Nov 6;390(6773):eadr9755.
More citations...News
July 24, 2025
ChimeraX 1.10.1 is now available, fixing the problem in 1.10 of repeat registration requests to some users.
June 26, 2025
The ChimeraX 1.10 production release is available! See the change log for what's new.
May 7, 2025
The ChimeraX 1.10 release candidate is available – please try it and report any issues. See the change log for what's new.
Previous news...Upcoming Events
UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325.
Feature Highlight
Pockets and cavities in protein structures can be identified with the
Find Cavities
tool or
kvfinder command.
These run KVFinder, a method based on surface shape
developed by the Lopes-de-Oliveira group at the
Brazilian Biosciences National Laboratory
(details...).
As shown in the figure, the results are listed in an interactive
cavity
list and can be displayed as dot clouds and/or surfaces.
The latest iteration of this feature
is available in ChimeraX 1.10 daily builds 4/17/25 and newer.
For image setup other than position and the specific cavity colors
(which are assigned randomly after a calculation), see the command file
kvfinder.cxc.
Example Image
Calmodulin (CaM) acts as a calcium sensor. When its four Ca++ sites
are fully occupied, it binds and modulates the activity of
various downstream proteins, including CaM-dependent protein kinase I (CaMKI).
Here, a complex between CaM and its target peptide from CaMKI
(PDB 1mxe) is shown with cartoons, a
transparent molecular surface, silhouette outlines, and
light soft
ambient occlusion. (If you prefer a less smudgy/rustic appearance, try using
light gentle
instead.)
For image setup other than positioning,
see the command file cam.cxc.
Find Cavities
Calmodulin and Target Peptide
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