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Featured Citations

Termination of the integrated stress response. De Miguel C, Thorkelsson SR et al. Science. 2026 Feb 19;397(6787):eadw5137.

Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization. Costello MS, Neumann B et al. Science. 2026 Feb 19;391(6787):825-830.

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes. Schwarz A, Mueller M et al. Science. 2026 Feb 19;391(6787):eadr4287.

Causal modelling of gene effects from regulators to programs to traits. Ota M, Spence JP et al. Nature. 2026 Feb 12;650(8101):399–408.

Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate. Ko D, Ruonala R et al. Science. 2026 Feb 12;391(6786):694-699.

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News

December 25, 2025

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The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

December 16, 2025

The ChimeraX 1.11 production release is available! See the change log for what's new.

November 21, 2025

The ChimeraX 1.11 release candidate is available – please try it and report any issues. See the change log for what's new. This will be the last release to support Red Hat Enterprise Linux 8 and its derivatives.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

simple lighting soft lighting

cryoEM Ambient Occlusion

A cryoelectron microscopy map of the 26S proteasome (EMD-4321) is shown at the author-recommended contour level in two different lighting modes: “simple” on the left and “soft” on the right. Soft lighting includes ambient lighting and shadowing (occlusion) and can be turned on with the command lighting soft or by clicking the Graphics icon computer generated image.

For setup of the righthand image, see the command file ambient.cxc.

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Example Image

neuraminidase flowers

Neuraminidase Flowers

Influenza neuraminidase is an enzyme that promotes the spread of influenza virus among host cells. It is the target of oseltamivir and related antiviral drugs. The image shows tetramers of neuraminidase (PDB 3k3a) styled as flowers. Three tetramers are in different shades of pink, with a central metal ion in white and nearby residues in yellow, and a fourth tetramer is colored green to resemble leaves. Each monomer or “petal” is a six-bladed β-propeller. For image setup other than orientation, see the command file flowers.cxc. The Chimera Image Gallery includes a similar image.

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