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Base-modified nucleotides mediate immune signaling in bacteria. Zeng Z, Hu Z et al. Science. 2025 Apr 25;388(6745):eads6055.
Structural mechanism of LINE-1 target-primed reverse transcription. Ghanim GE, Hu H et al. Science. 2025 Apr 25;388(6745):eads8412.
Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology. Sanguankiattichai N, Chandrasekar B et al. Science. 2025 Apr 18;388(6744):297-303.
Structure of human PINK1 at a mitochondrial TOM-VDAC array. Callegari S, Kirk NS et al. Science. 2025 Apr 18;388(6744):303-310.
Structural pathway for PI3-kinase regulation by VPS15 in autophagy. Cook ASI, Chen M et al. Science. 2025 Apr 11;388(6743):eadl3787.
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UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325.
Feature Highlight
Protein α-helices can be shown as curved-cylinder “tubes“
with the
cartoon style
command. Helix tube mode is an alternative to the standard spiraling ribbons,
and both modes are fully integrated with coil and β-strand cartoons.
The structure at left is an AMPA-subtype glutamate receptor
bound to the antiepileptic drug perampanel
(PDB 5l1f).
The receptor is tetrameric, and each chain is rainbow
color-coded from blue at the N-terminus to red at the C-terminus.
Four molecules of perampanel (pink)
are bound near the bottom, between the transmembrane domain and the
rest of the receptor. For image setup other than orientation,
see the command file ampar.cxc.
See also: Presets menu
Example Image
Calmodulin (CaM) acts as a calcium sensor. When its four Ca++ sites
are fully occupied, it binds and modulates the activity of
various downstream proteins, including CaM-dependent protein kinase I (CaMKI).
Here, a complex between CaM and its target peptide from CaMKI
(PDB 1mxe) is shown with cartoons, a
transparent molecular surface, silhouette outlines, and
light soft
ambient occlusion. (If you prefer a less smudgy/rustic appearance, try using
light gentle
instead.)
For image setup other than positioning,
see the command file cam.cxc.
Curved Helix Cylinders
Calmodulin and Target Peptide
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