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Targeting cancer with small-molecule pan-KRAS degraders. Popow J, Farnaby W et al. Science. 2024 Sep 20;385(6715):1338-1347.
Large library docking identifies positive allosteric modulators of the calcium-sensing receptor. Liu F, Wu CG et al. Science. 2024 Sep 20;385(6715):eado1868.
Mapping glycoprotein structure reveals Flaviviridae evolutionary history. Mifsud JCO, Lytras S et al. Nature. 2024 Sep 19;633(8030):695–703.
NAC guides a ribosomal multienzyme complex for nascent protein processing. Lentzsch AM, Yudin D et al. Nature. 2024 Sep 19;633(8030):718–724.
SymProFold: Structural prediction of symmetrical biological assemblies. Buhlheller C, Sagmeister T et al. Nat Commun. 2024 Sep 18;15(1):8152.
More citations...News
August 1, 2024
Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable August 1, 3-6 pm PDT.
June 17-18, 2024
Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable June 17-18 PDT.
June 13, 2023
The ChimeraX 1.8 production release is available! See the change log for what's new.
Previous news...Upcoming Events
UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325, Chan Zuckerberg Initiative grant EOSS4-0000000439, and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.
Feature Highlight
The MOLEonline Server calculates channels in protein structures and provides several types of analyses. Results can be downloaded in several different formats, including JSON.
A JSON file downloaded from the MOLEonline Server can be opened in ChimeraX version 1.5 and newer. A sphere model is generated for each channel in the file, and if the file contains more than one channel, a slider interface will appear for flipping through them one by one. Since the channels are individual models in ChimeraX, it is also easy to view more than one at the same time, change their colors, etc. using the Model Panel and/or commands. For image setup, see the command file 2dkh-mole.cxc and data file 2dkh-channels.json. See also the MOLE Channel Coloring by Property tutorial.
More features...Example Image
The architecture of the human ribosome has been determined at near-atomic resolution by electron microscopy (Anger et al., Nature 497:80 (2013)). The structure, comprising 82 proteins and five RNA molecules, is shown with shadows cast from all directions to accentuate depth. In the background are schematic representations of contacts between the component molecules.
See the image setup script card.cxc using the 'Tis the Season color palette (credit to MrsP). See also the RBVI holiday card gallery.
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