about projects people publications resources resources visit us visit us search search

Quick Links

Featured Citations

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin. Piper SJ, Brillault L et al. Nat Commun. 2019 Apr 26;10(1):1952.

Structure reveals a mechanism of CRISPR-RNA-guided nuclease recruitment and anti-CRISPR viral mimicry. Rollins MF, Chowdhury S et al. Mol Cell. 2019 Apr 4;74(1):132-142.e5.

Protein denaturation at the air-water interface and how to prevent it. D'Imprima E, Floris D et al. eLife. 2019 Apr 1;8. pii: e42747.

Structural snapshots of 26S proteasome reveal tetraubiquitin-induced conformations. Ding Z, Xu C et al. Mol Cell. 2019 Mar 21;73(6):1150-1161.e6.

Unexpected receptor functional mimicry elucidates activation of coronavirus fusion. Walls AC, Xiong X et al. Cell. 2019 Feb 21;176(5):1026-1039.e15.

See also: RCSB PDB Images
More citations...

News

May 23, 2019

A ChimeraX 0.9 release candidate is available – please try it and report any issues.

December 17, 2018

ChimeraX version 0.8 is available. See the change log for what's new.

August 7, 2018

ChimeraX version 0.7 is available. See the change log for what's new.

Previous news...

Upcoming Events


UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see licensing.

ChimeraX development is supported in part by grants from the National Institutes of Health (currently R01-GM129325, previously P41-GM103311).

Feature Highlight

Morphing Movie

Morphing between atomic structures can be calculated wih the morph command and played back in an animation. This movie shows morphing between two conformations of the FGFR1 kinase domain:

  • inactive structure (PDB 3C4F, chain A)
  • activated structure (PDB 3GQI, chain A) with phosphorylated tyrosines and bound ATP analog
The tyrosine side chains and ATP analog are color-coded by element: light blue carbon, red oxygen, blue nitrogen, and orange phosphorus.

Morphing and other setup was done with the command file kmorph-prep.cxc, followed by interactively positioning the structure and saving the view, then running kmorph-play.cxc to add 2D labels and record the movie.

More features...

Example Image

neuraminidase flowers

Potassium Channel-Calmodulin Complex

KCNQ1 is the pore-forming subunit of a cardiac potassium channel. It binds to calmodulin, and mutations in either of these proteins can cause congenital long QT syndrome, a dangerous propensity for irregular heartbeats. In the image, a structure of the KCNQ1/calmodulin complex (PDB 5vms) has been assembled into the native tetrameric form with the sym command. The view is from the cytoplasmic side, with KCNQ1 shown as surfaces, calmodulin as cartoons, and calcium ions as balls. A pastel palette from ColorBrewer has been used to color the surfaces, darkened with color modify for the cartoons, and “rotated” 45° in hue for the ions. See the command file colormod.cxc.

More images...



About RBVI | Projects | People | Publications | Resources | Visit Us

Copyright 2018 Regents of the University of California. All rights reserved.