Structural basis of nucleosome retention during transcription elongation. Filipovski M, Soffers JHM et al. Science. 2022 Jun 17;376(6599):1313-1316.
Mechanism of mitoribosomal small subunit biogenesis and preinitiation. Itoh Y, Khawaja A et al. Nature. 2022 Jun 16;606(7914):603-608.
Structural remodeling of ribosome associated Hsp40-Hsp70 chaperones during co-translational folding. Chen Y, Tsai B et al. Nat Commun. 2022 Jun 14;13(1):3410.
Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold. Fontana P, Dong Y et al. Science. 2022 Jun 10;376(6598):eabm9326.
AI-based structure prediction empowers integrative structural analysis of human nuclear pores. Mosalaganti S, Obarska-Kosinska A et al. Science. 2022 Jun 10;376(6598):eabm9506.More citations...
June 10, 2022
May 10, 2022
December 20, 2021
UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.
ChimeraX is developed with support from National Institutes of Health R01-GM129325 and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.
Rotamers is an interface for showing amino acid sidechain rotamers and optionally replacing the original sidechain, also implemented as the swapaa command. The rotamers can be shown all at once, as in the figure, or individually by choosing rows in the dialog.
The figure shows binding-site residues of the thyroid hormone receptor β with hormone bound, PDB 3gws. Rotamers for the hormone-resistance mutations N331H and L346R are shown as partially transparent sticks, with H-bonds (light blue dashed line) and clashes (light purple dashed lines) calculated for the histidine rotamers at position 331. The rotamer-list dialog for this position is also shown. Command script rotamers.cxc contains the initial, noninteractive part of the setup.
These mutations are described in Cardoso et al., Endocrine (2020). Although one histidine rotamer may be able to form the same pocket-stabilizing H-bond as the wild-type asparagine, it also clashes with several atoms (third row in the dialog). H-bonds and clashes are not shown for the arginine rotamers at 346, but they all clash significantly with the hormone and/or other pocket atoms.More features...
Atomic B-factor values are read from PDB and mmCIF input files and assigned as attributes that can be shown with coloring and used in atom specification. This example shows B-factor variation within a structure of the HIV-1 protease bound to an inhibitor (PDB 4hvp). For complete image setup, including positioning, color key, and label, see the command file bfactor.cxc.
About RBVI | Projects | People | Publications | Resources | Visit Us
Copyright 2018 Regents of the University of California. All rights reserved.