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Glutamate gating of AMPA-subtype iGluRs at physiological temperatures. Kumar Mondal A, Carrillo E et al. Nature. 2025 May 15;641(8063):788–796.

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis. Peng R, Xu X et al. Science. 2025 May 15;388(6748):eadq7597.

High-resolution characterization of ex vivo AAT polymers by solution-state NMR spectroscopy. Lowen SM, Waudby CA et al. Sci Adv. 2025 May 9;11(19):eadu7064.

The RAD52 double-ring remodels replication forks restricting fork reversal. Honda M, Razzaghi M et al. Nature. 2025 May 8;641(8062):512–519.

Snapshots of acyl carrier protein shuttling in human fatty acid synthase. Schultz K, Costa-Pinheiro P et al. Nature. 2025 May 8;641(8062):520–528.

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News

May 7, 2025

The ChimeraX 1.10 release candidate is available – please try it and report any issues. See the change log for what's new.

March 19, 2025

Wiley most-cited-paper medallion
UCSF ChimeraX: Tools for structure building and analysis is one of the 10 most cited papers published in Protein Science in 2023!

March 1, 2025

Bluesky logo Follow UCSF ChimeraX on BlueSky! @chimerax.ucsf.edu

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

thermal ellipsoids for 1jw8

Thermal Ellipsoids

Anisotropic B-factor data can be shown as thermal ellipsoids, axes, or ellipses with the aniso command or the Thermal Ellipsoids tool. The image shows myoglobin structure 1jw8 with thermal ellipsoid representations of the heme residue and protein sidechains that ligate or form H-bonds with the heme. Metal coordination bonds are shown as purple dashed lines and H-bonds as gold dashed lines.

For image setup other than position, see the command file myo-aniso.cxc (requires ChimeraX version 1.10 from February 2025 or newer).

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Example Image

neuraminidase flowers

Neuraminidase Flowers

Influenza neuraminidase is an enzyme that promotes the spread of influenza virus among host cells. It is the target of oseltamivir and related antiviral drugs. The image shows tetramers of neuraminidase (PDB 3k3a) styled as flowers. Three tetramers are in different shades of pink, with a central metal ion in white and nearby residues in yellow, and a fourth tetramer is colored green to resemble leaves. Each monomer or “petal” is a six-bladed β-propeller. For image setup other than orientation, see the command file flowers.cxc. The Chimera Image Gallery includes a similar image.

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