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Cryo-electron microscopy structures of human cone visual pigments. Peng Q, Li J et al. Science. 2026 Jun 25;392(6805):eadz8141.
Steric hindrance of antibody binding in an Omicron spike fusion intermediate. Bao Z, Liu Z et al. Nature. 2026 Jun 18;654(8119):762–770.
Structural basis of fungal β-1,3-glucan synthase inhibition by caspofungin. Ren Z, Chhetri A et al. Nature. 2026 Jun 10;654(8118):547–555.
Myosin forces remodel F-actin for mechanosensitive protein recognition. Carl AG, Reynolds MJ et al. Nature. 2026 Jun 4;654(8117):240–249.
A high-throughput selection system for fast-acting covalent protein drugs. Fan Q, Mei J et al. Science. 2026 May 28;392(6801):eadv3081.
Previously featured citations...Chimera Search
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June 25, 2026
Chimera production release 1.20 is now available, fixing problems on Mac OS Tahoe (1.20 release notes).
December 25, 2025
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September 22, 2025
Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.
Previous news...Upcoming Events
UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.
We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).
Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.
Feature Highlight
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The Metal Geometry tool facilitates analysis of metal-binding sites. It lists potential metal-coordinating atoms (nearby nucleophilic heteroatoms) and suggests likely coordination geometries. An idealized geometry can be depicted with solid arrows, as shown in the figure for the octahedral coordination of Mn++ by six atoms, and the coordination pseudobonds in the structure can be updated to match the chosen geometry.
(More features...)
Gallery Sample
Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.
See also the RBVI holiday card gallery.
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