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Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Warren AL, Lankri D et al. Nature. 2024 Jun 6;629(8015):237–246.

Observation of a promethium complex in solution. Driscoll DM, White FD et al. Nature. 2024 May 23;629(8013):819-823.

Stepwise activation of a metabotropic glutamate receptor. Krishna Kumar K, Wang H et al. Nature. 2024 May 23;629(8013):951–956.

Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1. Son Y, Kenny TC et al. Nature. 2024 May 16;629(8012):710–716.

Structural and molecular basis of choline uptake into the brain by FLVCR2. Cater RJ, Mukherjee D et al. Nature. 2024 May 16;629(8012):704–709.

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June 17-18, 2024

Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable June 17-18 PDT.

October 30-31, 2023

Planned downtime: The Chimera and ChimeraX websites and associated web services will be unavailable Oct 30 8am PDT – Oct 31 11:59pm PDT.

April 19, 2023

Chimera production release 1.17.1 is now available, fixing an issue with 1.17 for Windows and Linux. See the release notes for details.

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Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

volume plane display

Volume Plane Display

Volume data can be shown a single plane (or slab) at a time with the Planes feature in Volume Viewer. Plane display can be set to oscillate along the data X, Y, or Z axis, or the plane location can be specified interactively with a slider.

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Gallery Sample


Thermosomes are hollow balls inside which proteins are folded. They are found in the cytosol of eukaryotes and in archaea. Eukaryotic thermosomes have 8 different protein subunits, while archaeal ones are composed of one, two or three different proteins. The one shown from Thermoplasma acidophilum has two distinct proteins colored blue and yellow, each present in 8 copies. The two proteins have 60% sequence identity and are very similar in structure. One monomer is shown as a ribbon. Actin and tubulin are folded by eukaryotic thermosomes.

Protein Data Bank model 1a6d.

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