Crystal structures of agonist-bound human cannabinoid receptor CB1. Hua T, Vemuri K et al. Nature. 2025 Oct 16;646(8085):754–758.

Docking for Smoothened antagonist chemotypes not susceptible to a vismodegib-resistance mutation. Titulaer WHC, Klindert S et al. Eur J Med Chem. 2025 Oct 15;296:117753.

Mechanism of DNA targeting by human LINE-1. Jin W, Yu C et al. Science. 2025 Oct 9;390(6769):eadu3433.

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling. Zhou C, Zhang M et al. Science. 2025 Oct 2;390(6768):eads8728.

Elucidating the structure and assembly mechanism of actinoporin pores in complex membrane environments. Arranz R, Santiago C et al. Sci Adv. 2025 Sep 26;11(39):eadv0683.

The molecular infrastructure of glutamatergic synapses in the mammalian forebrain. Peukes J, Lovatt C et al. eLife. 2025 Sep 25;13:RP100335.

Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission. White KI, Khan YA et al. Nat Commun. 2025 Sep 24;16(1):8371.

Structural and functional characterization of human sweet taste receptor. Shi Z, Xu W et al. Nature. 2025 Sep 18;645(8081):801–808.

Structural characterization of five functional states of metabotropic glutamate receptor 8. Zhao J, Deng Y et al. Mol Cell. 2025 Sep 18;85(18):3460-3473.e6.

ACLY inhibition promotes tumour immunity and suppresses liver cancer. Gautam J, Wu J et al. Nature. 2025 Sep 11;645(8080):507–517.

Structure and function of a huge photosystem I-fucoxanthin chlorophyll supercomplex from a coccolithophore. Shen L, Ren F et al. Science. 2025 Sep 11;389(6765):eadv2132.

Amyloid-β oligomers, curvilinear and annular assemblies, imaged by cryo-ET, cryo-EM, and AFM. Liang R, Khursheed A et al. Sci Adv. 2025 Aug 29;11(35):eadx9030.

Diffusing protein binders to intrinsically disordered proteins. Liu C, Wu K et al. Nature. 2025 Aug 21;644(8077):809–817.

Structural determinants of rotavirus proteolytic activation. Asensio-Cob D, Mata CP et al. PLoS Pathog. 2025 Aug 12;21(8):e1013063.

The role of metabolism in shaping enzyme structures over 400 million years. Lemke O, Heineike BM et al. Nature. 2025 Aug 7;644(8075):280–289.

Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex. MacLean AE, Shikha S et al. Nat Struct Mol Biol. 2025 Aug;32(8):1424-1433.

Allosteric modulation and biased signalling at free fatty acid receptor 2. Zhang X, Guseinov AA et al. Nature. 2025 Jul 31;643(8074):1428–1438.

Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans. Willis JR, Prabhakaran M et al. Science. 2025 Jul 31;389(6759):eadr8382.

Structural analysis of HER2-trastuzumab complex reveals receptor conformational adaptation. Vacca S, Gragera M et al. Sci Adv. 2025 Jul 25;11(30):eadu9945.

Structural insights into human Pol III transcription initiation in action. Wang Q, Ren Y et al. Nature. 2025 Jul 24;643(8073):1127–1134.

Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning. Kaur U, Wu H et al. Science. 2025 Jul 17;389(6757):eadr3831.

Modeling binding selectivity of xylene isomers in resorcin[4]arene-based organo- and metallo-cavitands. Norjmaa G, Yu Y et al. J Org Chem. 2025 Jul 11;90(27):9327-9335.

Substrate recognition and cleavage mechanism of the monkeypox virus core protease. Gao Y, Xie X et al. Nature. 2025 Jul 3;643(8070):271–279.

Improving the solubility of single domain antibodies using VH-like hallmark residues. Uto Y, Nakakido M et al. Protein Sci. 2025 Jul;34(7):e70189.

Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers of the human secretin receptor in live cells. Stoneman MR, Killeen TD et al. Commun Biol. 2025 Jul 1;8(1):966.

Engineered CD4 TCR T cells with conserved high-affinity TCRs targeting NY-ESO-1 for advanced cellular therapies in cancer. Saillard M, Cenerenti M et al. Sci Adv. 2025 Jun 27;11(26):eadu5754.

A MERS-CoV-like mink coronavirus uses ACE2 as an entry receptor. Wang N, Ji W et al. Nature. 2025 Jun 19;642(8068):739–746.

Cryo-EM reveals structural diversity in prolate-headed mycobacteriophage Mycofy1. Li X, Shao Q et al. J Mol Biol. 2025 Jun 15;437(12):169126.

Conformational cycle and small-molecule inhibition mechanism of a plant ABCB transporter in lipid membranes. Liu Y, Liao M. Sci Adv. 2025 Jun 13;11(24):eadv9721.

Cat1 forms filament networks to degrade NAD+ during the type III CRISPR-Cas antiviral response. Baca CF, Majumder P et al. Science. 2025 Jun 12;388(6752):eadv9045.

Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM. Klebl DP, McMillan SN et al. Nature. 2025 Jun 12;642(8067):519–526.

Structural insights into chromatin remodeling by ISWI during active ATP hydrolysis. Sia Y, Pan H et al. Science. 2025 Jun 5;388(6751):eadu5654.

Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation. Upadhyay T, Woods EC et al. Nat Commun. 2025 May 30;16(1):5046.

Wastewater sequencing from a rural community enables identification of widespread adaptive mutations in a SARS-CoV-2 alpha variant. Conway MJ, Novay MP et al. Sci Rep. 2025 May 28;15(1):18657.

Building molecular model series from heterogeneous CryoEM structures using Gaussian mixture models and deep neural networks. Chen M. Commun Biol. 2025 May 25;8(1):798.

Oxidation of retromer complex controls mitochondrial translation. Zhang J, Ali MY et al. Nature. 2025 May 22;641(8064):1048–1058.

MagIC-Cryo-EM, structural determination on magnetic beads for scarce macromolecules in heterogeneous samples. Arimura Y, Konishi HA, Funabiki H. eLife. 2025 May 20;13:RP103486.

Structure and mechanism of the plastid/parasite ATP/ADP translocator. Lin H, Huang J et al. Nature. 2025 May 15;641(8063):797–804.

Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis. Zhang S, Lin H et al. Nature. 2025 May 8;641(8062):476-485.

Structure of mitochondrial pyruvate carrier and its inhibition mechanism. He Z, Zhang J et al. Nature. 2025 May 1;641(8061):250–257.

Structures and mechanism of the human mitochondrial pyruvate carrier. Liang J, Shi J et al. Nature. 2025 May 1;641(8061):258-265.

Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. Lin H, Ma C et al. Science. 2025 May 1;388(6746):eado4188.

Chanoclavine synthase operates by an NADPH-independent superoxide mechanism. Chen CC, Yu ZP et al. Nature. 2025 Apr 17;640(8059):840-846.

A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein. Van Damme E, Abeywickrema P et al. Nature. 2025 Apr 10;640(8058):506–513.

The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation. Stacey JCV, Hrebík D et al. Nature. 2025 Apr 3;640(8057):258–264.

Structures of a T1-like siphophage reveal capsid stabilization mechanisms and high structural similarities with a myophage. Cai C, Wang Y et al. Structure. 2025 Apr 3;33(4):663-676.e2.

Structure of ATP synthase from an early photosynthetic bacterium Chloroflexus aurantiacus. Zhang X, Wu J et al. Proc Natl Acad Sci USA. 2025 Apr;122(13):e2425824122.

Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2. Kugawa M, Kawakami K et al. Nat Commun. 2025 Mar 26;16(1):2809.

Molecular architectures of centrosomes in C. elegans embryos visualized by cryo-electron tomography. Tollervey F, Rios MU et al. Dev Cell. 2025 Mar 24;60(6):885-900.e5.

Balanced plant helper NLR activation by a modified host protein complex. Huang S, Wang J et al. Nature. 2025 Mar 13;639(8054):447–455.

Activation and inhibition mechanisms of a plant helper NLR. Xiao Y, Wu X et al. Nature. 2025 Mar 13;639(8054):438–446.

Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects. Tummino TA, Iliopoulos-Tsoutsouvas C et al. Nat Commun. 2025 Mar 6;16(1):2237.

A widespread plant defense compound disarms bacterial type III injectisome assembly. Miao P, Wang H et al. Science. 2025 Feb 28;387(6737):eads0377.

RNA control of reverse transcription in a diversity-generating retroelement. Handa S, Biswas T et al. Nature. 2025 Feb 27;638(8052):1122–1129.

Hierarchical design of pseudosymmetric protein nanocages. Dowling QM, Park YJ et al. Nature. 2025 Feb 13;637(8050):553–561.

Structure and assembly of the dystrophin glycoprotein complex. Wan L, Ge X et al. Nature. 2025 Jan 30;637(8048):1252–1260.

Structural basis for the conformational protection of nitrogenase from O₂. Narehood SM, Cook BD et al. Nature. 2025 Jan 23;637(8047):991–997.

Molecular mechanism of IgE-mediated FcεRI activation. Chen M, Su Q, Shi Y. Nature. 2025 Jan 9;637(8045):453–460.

High-resolution cryo-EM using a common LaB6 120-keV electron microscope equipped with a sub-200-keV direct electron detector. Venugopal H, Mobbs J et al. Sci Adv. 2025 Jan 3;11(1):eadr0438.

Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1. López VG, Valencia-Sánchez MI et al. Nature. 2024 Dec 19;636(8043):755–761.

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma. Chen YJ, Iyer SV et al. Nature. 2024 Dec 12;636(8042):466-473.

Active-reset protein sensors enable continuous in vivo monitoring of inflammation. Zargartalebi H, Mirzaie S et al. Science. 2024 Dec 6;386(6726):1146-1153.

DMSO might impact ligand binding, capsid stability, and RNA interaction in viral preparations. Wald J, Goessweiner-Mohr N et al. Sci Rep. 2024 Dec 6;14(1):30408.

Nucleosome flipping drives kinetic proofreading and processivity by SWR1. Girvan P, Jalal ASB et al. Nature. 2024 Dec 5;635(8041):251–257.

Structural basis of orientated asymmetry in a mGlu heterodimer. Huang W, Jin N et al. Nat Commun. 2024 Nov 28;15(1):10345.

Structure of the human TSC:WIPI3 lysosomal recruitment complex. Bayly-Jones C, Lupton CJ et al. Sci Adv. 2024 Nov 22;10(47):eadr5807.

Structural basis of mRNA decay by the human exosome-ribosome supercomplex. Kögel A, Keidel A et al. Nature. 2024 Nov 7;635(8037):237-242.

Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4. Rathnayake SS, Erramilli SK et al. Structure. 2024 Nov 7;32(11):1936-1951.e5.

Brain malformations and seizures by impaired chaperonin function of TRiC. Kraft F, Rodriguez-Aliaga P et al. Science. 2024 Nov 1;386(6721):516-525.

REliable PIcking by Consensus (REPIC): a consensus methodology for harnessing multiple cryo-EM particle pickers. Cameron CJF, Seager SJH et al. Commun Biol. 2024 Oct 31;7(1):1421.

Dynamic allostery drives autocrine and paracrine TGF-β signaling. Jin M, Seed RI et al. Cell. 2024 Oct 31;187(22):6200-6219.e23.

Small molecule assembly agonist alters the dynamics of hepatitis B virus core protein dimer and capsid. Kant R, Lee LS et al. J Am Chem Soc. 2024 Oct 23;146(42):28856-28865.

Mechanism of bacterial predation via ixotrophy. Lien YW, Amendola D et al. Science. 2024 Oct 18;386(6719):eadp0614.

Catalytic asymmetric fragmentation of cyclopropanes. Raut RK, Matsutani S et al. Science. 2024 Oct 11;386(6718):225-230.

Ribosomes hibernate on mitochondria during cellular stress. Gemin O, Gluc M et al. Nat Commun. 2024 Oct 8;15(1):8666.

Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations. You Q, Feng X et al. Commun Biol. 2024 Sep 28;7(1):1202.

Fibrin drives thromboinflammation and neuropathology in COVID-19. Ryu JK, Yan Z et al. Nature. 2024 Sep 26;633(8031):905–913.

Germline mutations in a G protein identify signaling cross-talk in T cells. Ham H, Jing H et al. Science. 2024 Sep 20;385(6715):eadd8947.

The hepatitis C virus envelope protein complex is a dimer of heterodimers. Augestad EH, Holmboe Olesen C et al. Nature. 2024 Sep 19;633(8030):704–709.

Binding of steroid substrates reveals the key to the productive transition of the cytochrome P450 OleP. Costanzo A, Fata F et al. Structure. 2024 Sep 5;32(9):1465-1476.e3.

Molecular architecture of coronavirus double-membrane vesicle pore complex. Huang Y, Wang T et al. Nature. 2024 Sep 5;633(8028):224–231.

FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions. Alcón P, Kaczmarczyk AP et al. Nature. 2024 Aug 29;632(8027):1165–1173.

Leptospira interrogans encodes a canonical BamA and three novel noNterm Omp85 outer membrane protein paralogs. Bettin EB, Grassmann AA et al. Sci Rep. 2024 Aug 28;14(1):19958.

Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor. Saha S, Khanppnavar B et al. Cell. 2024 Aug 22;187(17):4751-4769.e25.

Transport and inhibition mechanisms of the human noradrenaline transporter. Hu T, Yu Z et al. Nature. 2024 Aug 22;632(8026):930–937.

Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain. Kefauver JM, Hakala M et al. Nature. 2024 Aug 15;632(8025):664-671.

An integrative structural study of the human full-length RAD52 at 2.2 Å resolution. Balboni B, Marotta R et al. Commun Biol. 2024 Aug 8;7(1):956.

Capsid structure of bacteriophage ΦKZ provides insights into assembly and stabilization of jumbo phages. Yang Y, Shao Q et al. Nat Commun. 2024 Aug 2;15(1):6551.

Mechanism of PCNA loading by Ctf18-RFC for leading-strand DNA synthesis. Yuan Z, Georgescu R et al. Science. 2024 Aug 2;385(6708):eadk5901.

Molecular mechanism of ligand gating and opening of NMDA receptor. Chou TH, Epstein M et al. Nature. 2024 Aug 1;632(8023):209–217.

Bis-sulfonamido-2-phenylbenzoxazoles validate the GroES/EL chaperone system as a viable antibiotic target. Godek J, Sivinski J et al. J Am Chem Soc. 2024 Jul 31;146(30):20845-20856.

Structure of the Hir histone chaperone complex. Kim HJ, Szurgot MR et al. Mol Cell. 2024 Jul 25;84(14):2601-2617.e12.

Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Chen J, Zehr EA et al. Nature. 2024 Jul 25;631(8022):905–912.

A μ-opioid receptor modulator that works cooperatively with naloxone. O'Brien ES, Rangari VA et al. Nature. 2024 Jul 18;631(8021):686–693.

Molecular mechanism of plasmid elimination by the DdmDE defense system. Loeff L, Adams DW et al. Science. 2024 Jul 12;385(6705):188-194.

Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Hu X, Ao W et al. Nature. 2024 Jul 11;631(8020):459–466.

Evolution and host-specific adaptation of Pseudomonas aeruginosa. Weimann A, Dinan AM et al. Science. 2024 Jul 5;385(6704):eadi0908.

Electric nuclear quadrupole coupling reveals dissociation of HCl with a few water molecules. Xie F, Tikhonov DS, Schnell M. Science. 2024 Jun 28;384(6703):1435-1440.

Structural insights into the cross-exon to cross-intron spliceosome switch. Zhang Z, Kumar V et al. Nature. 2024 Jun 27;630(8018):1012-1019.