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High-resolution cryo-EM analysis of the therapeutic Pseudomonas phage Pa223. Hou CD, Bellis N et al. J Mol Biol. 2025 Nov 1;437(21):169386.

Crystal structures of agonist-bound human cannabinoid receptor CB1. Hua T, Vemuri K et al. Nature. 2025 Oct 16;646(8085):754–758.

Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites. Zhang Z, Todeschini TC et al. Cell. 2025 Oct 16;188(21):5862-5877.e23.

Docking for Smoothened antagonist chemotypes not susceptible to a vismodegib-resistance mutation. Titulaer WHC, Klindert S et al. Eur J Med Chem. 2025 Oct 15;296:117753.

Mechanism of DNA targeting by human LINE-1. Jin W, Yu C et al. Science. 2025 Oct 9;390(6769):eadu3433.

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News

September 22, 2025

Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.

March 6, 2025

Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (details...).

December 25, 2024

The RBVI wishes you a safe and happy holiday season! See our 2024 card and the gallery of previous cards back to 1985.

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Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

User-Driven Analysis

User-Driven Analysis

Users can easily import structure-related data into Chimera in the form of attributes, or values associated with atoms, residues, or models. The data can be imported with Define Attribute and then represented visually with color ranges, atomic radii, or "worm" thickness. Such data can also be manipulated programmatically in Chimera, and in fact Chimera was designed with extensibility and programmability in mind. It is largely implemented in Python, with certain features coded in C++ for efficiency. Python is an easy-to-learn interpreted language with object-oriented features. All of Chimera's functionality is accessible through Python and users can implement their own algorithms and extensions without any Chimera code changes, so any such custom extensions will continue to work across Chimera releases. Many programming examples are provided to assist extension writers.

(More features...)

Gallery Sample

Peroxiredoxin Wreath

Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.

See also the RBVI holiday card gallery.

(More samples...)


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