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The molecular basis of force selectivity by PIEZO2. Mulhall EM, Yarishkin O et al. Nature. 2026 May 7;653(8113):297–305.
Human DHX29 detects nonoptimal codon usage to regulate mRNA stability. Hia F, Wu Y et al. Science. 2026 May 7;392(6798):eadw0288.
CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome. Shi H, Wang X et al. Nature. 2026 Apr 30;652(8112):1375–1383.
Complement inhibition by a unique cluster of immunomodulatory outer surface proteins of Borrelia recurrentis. Röttgerding F, Reyer F et al. Nat Commun. 2026 Apr 29;17(1):3900.
Pre-incision structures reveal principles of DNA nucleotide excision repair. Li ECL, Kim J et al. Nature. 2026 Apr 23;652(8111):1060–1067.
Previously featured citations...Chimera Search
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December 25, 2025
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September 22, 2025
Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.
March 6, 2025
Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (1.19 release notes).
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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.
We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).
Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.
Feature Highlight
Different conformations and even different proteins can be compared by morphing from one structure to another. Users can specify the method of coordinate interpolation and how many intermediate structures should be generated. The result is displayed in Chimera's trajectory viewer, MD Movie. The morph can then be saved in coordinate form or recorded as an animation.
(More features...)
Gallery Sample
Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.
See also the RBVI holiday card gallery.
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