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Structural basis of mRNA decay by the human exosome-ribosome supercomplex. Kögel A, Keidel A et al. Nature. 2024 Nov 7;635(8037):237-242.

Brain malformations and seizures by impaired chaperonin function of TRiC. Kraft F, Rodriguez-Aliaga P et al. Science. 2024 Nov 1;386(6721):516-525.

Small molecule assembly agonist alters the dynamics of hepatitis B virus core protein dimer and capsid. Kant R, Lee LS et al. J Am Chem Soc. 2024 Oct 23;146(42):28856-28865.

Mechanism of bacterial predation via ixotrophy. Lien YW, Amendola D et al. Science. 2024 Oct 18;386(6719):eadp0614.

Catalytic asymmetric fragmentation of cyclopropanes. Raut RK, Matsutani S et al. Science. 2024 Oct 11;386(6718):225-230.

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News

October 14, 2024

Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable starting Monday, Oct 14 10 AM PDT, continuing throughout the week and potentially the weekend (Oct 14-20).

August 1, 2024

Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable August 1, 3-6 pm PDT.

July 16, 2024

Chimera production release 1.18 is now available. See the release notes for details.

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Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

Fly-through Animation

The fly command can animate a flight through molecular structures. Click the example image to fly along the RNA being copied by rotavirus RNA polymerase (PDB 2r7r), an enzyme that replicates the 11 segments of viral RNA. See a video showing how this animation was made.

(More features...)

Gallery Sample

Binding Site Similarity

β-1,4-glycanase (gold, PDB 1exp) and cellobiohydrolase I (cyan, PDB 1cel) have similar glucose-binding sites but different folds. Ribbons were slimmed with Ribbon Style Editor and the title and captions were added with 2D Labels (see image how-to). (More samples...)


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