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Correlation between solvation free energy and solute-solvent interaction energy in energy representation theory. Maruyama Y, Matubayasi N. J Phys Chem B. 2025 Dec 25;129(51):13230-13241.

Structural snapshots capture nucleotide release at the μ-opioid receptor. Khan S, Tyson AS et al. Nature. 2025 Dec 18;648(8094):755–763.

Bottom-up design of Ca2+ channels from defined selectivity filter geometry. Liu Y, Weidle C et al. Nature. 2025 Dec 11;648(8093):468–476.

Molecular insights into species-specific ACE2 recognition of coronavirus HKU5. Zhang Y, Li Y et al. Nat Commun. 2025 Dec 4;16(1):10889.

Structural and functional characterization of a metagenomically derived γ-type carbonic anhydrase and its engineering into a hyperthermostable esterase. Bodourian CS, Imran M et al. Protein Sci. 2025 Dec;34(12):e70396.

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December 25, 2025

The RBVI wishes you a safe and happy holiday season! See our 2025 card and the gallery of previous cards back to 1985.

September 22, 2025

Mac users may wish to defer upgrading to MacOS Tahoe. Currently on that OS the Chimera graphics window is shifted so that it covers the command and status lines.

March 6, 2025

Chimera production release 1.19 is now available, fixing the ability to fetch structures from the PDB (details...).

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Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.
computer generated image

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

Nucleotides

Special representations of DNA and RNA can be displayed with the Nucleotides tool or the command nucleotides. Different levels of abstraction are available. The figure shows a ribbon backbone combined with the following sidechain (sugar/base) options:

  • ladder rungs
  • filled-ring atomic representations
  • "lollipops" in which bases are shown as ellipsoids and sugars as tubes
Bases can also be displayed as boxes or elliptical tubes, with or without bumps to indicate orientation. The colors of the special representations will update automatically to match the corresponding atoms.

(More features...)

Gallery Sample

Sliced Potassium Channel

Potassium channel (Protein Data Bank entry 1bl8) on a dark slate blue background with potassium ions shown in firebrick. The channel is comprised of four chains. Each chain has been rainbow-colored from blue at the N-terminus to red at the C-terminus, but only the surface of the channel is shown. The surface has been sliced with a per-model clipping plane. The surface cap color is plum except with opacity set to 0.8. The shininess and brightness have been set to 128 and 8, respectively, and the lights on the scene have been moved from their default positions. The subdivision quality (related to the smoothness of the spherical ions) is 5.0, and the molecular surface was computed with probe radius and vertex density set to 1.0 and 6.0, respectively. (More samples...)


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