Address:
Resource for Biocomputing, Visualization, and Informatics (RBVI)
University of California, M/S 2240
600 16th Street, Rm N472
San Francisco, CA 94158-2517
Phone: 415-476-2299
Fax: 415-502-1755
Email: tef [at] cgl.ucsf.edu
Assistant: Ms. Kris Casler
415-476-3138
lck [at] cgl.ucsf.edu
Education/Affiliations:
- B.Sc. University of Minnesota,
Electrical Engineering and Computer Science, 1971
- Ph.D. University of California, San Francisco,
Medical Information Science, 1986
- Professor, Departments of
Pharmaceutical Chemistry and
Bioengineering & Therapeutic Sciences, UCSF
- Chair, UCSF Biological and Medical Informatics Graduate Program
- Member, UCSF/UCB Bioengineering Graduate Program
- Member, UCSF Biophysics Graduate Program
- Member, UCSF Chemistry and Chemical Biology Graduate Program
- Member, UCSF Pharmaceutical Sciences and Pharmacogenomics Graduate Program
- Member, California Institute for Quantitative Biosciences (QB3)
- Member, UCSF Cancer Center
- Past Member, National Library of Medicine Board of Scientific Counselors
Research Activities:
See my UCSF Profiles link.
My research focuses on developing software tools and advanced web-based
resources for the visualization and analysis of molecular structure
at scales ranging from the atomic to the supramolecular. We create
tools for handling and integrating diverse types of biomolecular data,
including atomic-resolution coordinates, density maps, sequences,
annotations, and networks. Our primary efforts are in the visualization
and analysis of structures of molecules and molecular assemblies, enzyme
sequence-structure-function relationships, and network representations of
protein similarity, binding interactions, and biological pathways. We
provide technologies to enable identifying the molecular bases of
disease and phenotypic variation, annotating proteins of unknown
function, identifying targets for drug development, designing drugs, and
engineering proteins with new functions. We have a strong track record of
creating well-documented robust software tools and disseminating these
in open-source form via our NCRR-funded Biomedical Technology Research
Center web site (www.rbvi.ucsf.edu)
so that other NIH-funded scientists can advance their own research
programs effectively.
Awards:
Selected Publications:
- Jewett AI, Huang CC, Ferrin TE, MINRMS: an efficient algorithm for determining protein structure similarity using root-mean-squared-distance, Bioinformatics, 2003 Mar 22, 19(5):625-34. PMID:12651721
- Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE, UCSF Chimera--a visualization system for exploratory research and analysis, J Comput Chem, 2004 Oct, 25(13):1605-12. PMID:15264254
- Goddard TD, Huang CC, Ferrin TE, Software extensions to UCSF chimera for interactive visualization of large molecular assemblies, Structure, 2005 Mar, 13(3):473-82. PMID:15766548
- Nord AS, Chang PJ, Conklin BR, Cox AV, Harper CA, Hicks GG, Huang CC, Johns SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, Soriano P, Stanford WL, Stryke D, von Melchner H, Wurst W, Yamamura K, Young SG, Babbitt PC, Ferrin TE, The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse, Nucleic Acids Res, 2006 Jan 1, 34(Database issue):D642-8. PMID:16381950 PMCID: PMC1347459
- Yoshikuni Y, Ferrin TE, Keasling JD, Designed divergent evolution of enzyme function, Nature, 2006 Apr 20, 440(7087):1078-82. PMID:16495946
- Pegg SC, Brown SD, Ojha S, Seffernick J, Meng EC, Morris JH, Chang PJ, Huang CC, Ferrin TE, Babbitt PC, Leveraging enzyme structure-function relationships for functional inference and experimental design: the structure-function linkage database, Biochemistry, 2006 Feb 28, 45(8):2545-55. PMID:16489747
- Couch GS, Hendrix DK, Ferrin TE, Nucleic acid visualization with UCSF Chimera, Nucleic Acids Res, 2006 Feb 14, 34(4):e29. PMID:16478715 PMCID: PMC1368656
- Meng EC, Pettersen EF, Couch GS, Huang CC, Ferrin TE, Tools for integrated sequence-structure analysis with UCSF Chimera, BMC Bioinformatics, 2006 Jul 12, 7:339. PMID:16836757 PMCID: PMC1570152
- Harper CA, Huang CC, Stryke D, Kawamoto M, Ferrin TE, Babbitt PC, Comparison of methods for genomic localization of gene trap sequences, BMC Genomics, 2006 Sep 18, 7:236. PMID:16982004 PMCID: PMC1617135
- Goddard TD, Huang CC, Ferrin TE, Visualizing density maps with UCSF Chimera, J Struct Biol, 2007 Jan, 157(1):281-7. PMID:16963278
- Morris JH, Huang CC, Babbitt PC, Ferrin TE, structureViz: linking Cytoscape and UCSF Chimera, Bioinformatics, 2007 Sep 1, 23(17):2345-7. PMID:17623706
- Goddard TD, Ferrin TE, Visualization software for molecular assemblies, Curr Opin Struct Biol, 2007 Oct, 17(5):587-95. PMID:17728125 PMCID: PMC2174518
- Atkinson HJ, Morris JH, Ferrin TE, Babbitt PC, Using sequence similarity networks for visualization of relationships across diverse protein superfamilies, PLoS One, 2009, 4(2):e4345. PMID:19190775 PMCID: PMC2631154
- Morris JH, Meng EC, Ferrin TE, Computational tools for the interactive exploration of proteomic and structural data, Mol Cell Proteomics, 2010 Aug, 9(8):1703-15. PMID:20525940 PMCID: PMC2938059
- Bromberg S, Chiu W, Ferrin TE, Workshop on molecular animation, Structure, 2010 Oct 13, 18(10):1261-5. PMID:20947014 PMCID: PMC3071847
- Apeltsin L, Morris JH, Babbitt PC, Ferrin TE, Improving the quality of protein similarity network clustering algorithms using the network edge weight distribution, Bioinformatics, 2011 Feb 1, 27(3):326-33. PMID:21118823 PMCID: PMC3031030
- Morris JH, Apeltsin L, Newman AM, Baumbach J, Wittkop T, Su G, Bader GD, Ferrin TE, clusterMaker: a multi-algorithm clustering plugin for Cytoscape, BMC Bioinformatics, 2011 Nov 9, 12:436. PMID:22070249 PMCID: PMC3262844
- Yang Z, Lasker K, Schneidman-Duhovny D, Webb B, Huang CC, Pettersen EF, Goddard TD, Meng EC, Sali A, Ferrin TE, UCSF Chimera, MODELLER, and IMP: an integrated modeling system, J Struct Biol, 2012 Sep, 179(3):269-78. PMID:21963794 PMCID: PMC3410985
- Lasker K, Velázquez-Muriel JA, Webb BM, Yang Z, Ferrin TE, Sali A, Macromolecular assembly structures by comparative modeling and electron microscopy, Methods Mol Biol, 2012, 857:331-50. PMID:22323229
PubMed search of
all publications authored by T.E. Ferrin,
or do the
same using Google Scholar.
Some Invited Lectures and Seminars:
From Long Ago:
- My UNIX kernel hacking days (circa late 70's and early 80's):
- The Daemon, the GNU, and the Penguin: A History of Free and Open Source
BSD and the CSRG
CSRG Members, Supporters, and Contributors
Interactive computer graphics with the UNIX time-sharing system
Modifying the PDP-11/70 mfpi instruction hardware
and the Letter reprinted from ;login:
that raised a few eyebrows
Heuristics for Disk Drive Positioning in 4.3BSD
25th Anniversary UNIX Playing Cards
- The early days of molecular graphics (mid 1970's):
- The first interactive color display of molecules
- My drag racing days (late 60's):
- Ky Michaelson's AA/GD dragsters [picture]
The Snow Dragster
Hydrogen Peroxide Rocket Dragsters
Other Fun or Interesting Links: