id summary reporter owner description type status priority milestone component version resolution keywords cc blockedby blocking notify_on_close platform project 5600 Allow global fitting avoid clashes with some already fit molecules olibclarke@… Tom Goddard "Begin forwarded message: From: Oliver Clarke via ChimeraX-users Subject: [chimerax-users] Fit in map sequentially with global search? Date: November 12, 2021 at 12:51:34 PM PST To: ChimeraX Users Help Reply-To: Oliver Clarke <> Hi, I frequently use the ""global search"" option of fitmap in chimera to identify the orientation of proteins or fragments in my map. Fitmap has an option, ""sequence"", allowing the sequential fitting of multiple structures to a map, after subtracting the density corresponding to the previous fit, but this is not compatible with global search. Would it be possible to add an option to fitmap in ChimeraX such that it considers clashes with designated existing models? This would be useful when one is trying to fit the density of a weakly occupied binding partner in the context of a larger known structure. Presently, when one uses fitmap with global search in such a case, the binding partner frequently gets sucked in to the stronger density for the host protein, even when the density for the binding partner is visually clear. Cheers Oli" enhancement assigned moderate Volume Data all ChimeraX