id	summary	reporter	owner	description	type	status	priority	milestone	component	version	resolution	keywords	cc	blockedby	blocking	notify_on_close	platform	project
18061	Allow ChimeraX to run Boltz-2 predictions on user's computer	Tom Goddard	Tom Goddard	"Boltz 2 released on June 6, 2025 and includes new features over Boltz 1 of interest to ChimeraX users.  It does ligand binding affinity prediction.  It also allows template structures.  The templates can be specified for each chain.  Supposedly the prediction can be forced to match the template to varying degrees.  It can predict B-factors and has prediction modes based on MD and NMR ensembles.

Since the 2.0 release there have been 5 releases fixing bugs, the latest 2.1.1 on June 11.

There are several new bugs that will affect running Boltz 2 on Mac, Windows and Linux, and new patches to my ChimeraX Boltz fork will be needed to make Boltz 2 usable.  And more user interfaces and command options will be needed to take advantage of new Boltz 2 features."	enhancement	assigned	moderate		Structure Prediction								all	ChimeraX