February 22, 2012
Movie showing molecules that bind to HIV RNA for the 2012 Biophysical Society meeting to be projected on a planetarium dome.
January 2013. New narration by Jim Weiss, new music by Nine Inch Nails, and updated credits at end of movie.
|Opening scene RNA wiggling. Clips P.||Fly over CD8 T-cell .|
Clips P, D.
|SIV virion with spikes|
between two cells. Clips P.
|Core particle. Clips P.||HIV RNA dimer. Clips P, P2.||Ribosome size comparison (3u5b, 3u5d) . Clips P,|
|Ribosome RNA decorated|
with 75 different proteins. (3u5c, 3u5e). Clips P,
|HIV RNA decorated with|
~1000 copies of nucleocapsid protein. Clips P,
|Close-up of nucleocapsid binding (1a1t). Clips P.||Dimerization kissing hairpin (2d1b). Clips P.||Extended dimerization (2d1a) promoted by NC. Clips P.|
|tRNA primer (1fir) and reverse transcriptase (3v6d). Clips P.||DNA-RNA hybrid with RNA cleaved segments that fly away. Clips P.||Form and fly along duplex DNA. Clips P.||Circularized DNA with strand swap coloring.  Clips P.|
|Integrase binding (3os1). Clips P.||Nuclear pore (EMDB 1097), pre-integation complex must pass through. Clips P.||Chromatin with HIV integrated as 50 nucleosomes (1zbb). Clips P.||TAT binding (2w2h) at TAR RNA (2kx5) site recruits P-TEFb (3mi9) to get full length transcript.  Clips P.||Rev (3lph) binding to RNA (1etf) and CRM (3gjx) to export unspliced RNA from nucleus. Clips P.||Credits. Clips P.|