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Modeling Collagen
We have recently completed studies of 0.5-1.0 nanosecond
molecular dynamics simulations of collagen-like peptides.
These peptides are used as models of native
and mutated collagens for studying the structural aspects
of the genetic collagenous disorder Osteogenesis imperfecta.
The molecular graphics image shown here
depicts a 10% contour of water occupancy of
a triple-mutant collagen-like peptide and was generated using MidasPlus.
For additional information, see
“Computational investigations of structural changes
resulting from point mutations in a collagen-like peptide,”
Teri E. Klein and Conrad C. Huang,
Biopolymers 49:167 (1999). Card design by Heidi Houtkooper.
The UCSF Computer Graphics Laboratory is supported by
the National Center for Research Resources
(grant P41-RR01081, Thomas Ferrin, Principal Investigator).
© 1998 Regents of the University of California.
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