Elaine C. Meng, PhD
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email:
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meng@cgl.ucsf.edu
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address:
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UCSF MC 2240
Genentech Hall Room N476B
600 16th Street
San Francisco, CA 94158-2517
My scientific interests are in protein structure/function and
computational chemistry. I am a Specialist in the
Babbitt group
and
UCSF Computer Graphics Laboratory (CGL).
The CGL is developing the molecular graphics and analysis program
Chimera.
As a member of the development team, I write the
Chimera User's Guide, interact with users, test the software, and
make suggestions.
Other laboratories I have worked in are the
Kuntz group
(docking and scoring),
the Kollman group
(molecular dynamics and free energy calculations),
the Cohen group
(structure-based drug design), and
the Bourne group
(structure/function of G proteins and GPCRs).
Background
I was born and raised in Ohio.
After attending a variety of educational institutions, I graduated from
the University of Cincinnati in 1988 with a degree in Pharmacy.
I am a registered pharmacist, but nonpracticing (Ohio license only).
My PhD thesis, entitled "Tools for Ligand Discovery and Design: Molecular
Docking and Structural Databases," was completed in 1993 in Prof.
Irwin "Tack" Kuntz' group, Dept. of Pharmaceutical Chemistry, UCSF.
I spent two years as a postdoc in Prof. Peter Kollman's group before
taking a staff position at UCSF (groups listed above; see also
my curriculum vitae).
I married
Eric Pettersen in October 1995.
My hobbies include playing the piano, reading,
solving crosswords, and finding typos.
Pictures:
Selected Publications
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Tools for integrated sequence-structure analysis with
UCSF Chimera:
E.C. Meng, E.F. Pettersen, G.S. Couch, C.C. Huang, and T.E. Ferrin,
BMC Bioinformatics 7, 339 (2006).
- UCSF Chimera - A Visualization System for Exploratory Research and
Analysis: E.F. Pettersen, T.D. Goddard, C.C. Huang, G.S. Couch,
D.M. Greenblatt, E.C. Meng, and T.E. Ferrin, J. Comput. Chem.
25, 1605 (2004).
- Superfamily Active Site Templates:
E.C. Meng, B.J. Polacco, and P.C. Babbitt,
Proteins 55, 962 (2004).
- Receptor activation: what does the rhodopsin structure tell
us?: E.C. Meng and H.R. Bourne, Trends Pharmacol. Sci.
22, 587 (2001).
- An Activation Switch in the Ligand Binding Pocket of the C5a
Receptor: B.O. Gerber, E.C. Meng, V. Dötsch, T.J. Baranski, and
H.R. Bourne, J. Biol. Chem. 276, 3394 (2001).
- Rhodopsin Sees the Light:
H.R. Bourne and E.C. Meng, Science 289, 733 (2000).
- Molecular Dynamics Studies of the Properties of Water around
Simple Organic Solutes:
E.C. Meng and P.A. Kollman, J. Phys. Chem.
100, 11460 (1996).
- Investigating the Anomalous Solvation Free Energies of
Amines with a Polarizable Potential:
E.C. Meng, J.W. Caldwell, and P.A. Kollman, J. Phys. Chem.
100, 2367 (1996).
- Evaluating Docked Complexes with the HINT Exponential
Function and Empirical Atomic Hydrophobicities:
E.C. Meng, I.D. Kuntz, D.J. Abraham, and G.E. Kellogg, J. Comput.-Aided
Mol. Des. 8, 299 (1994).
- Automated Docking with Grid-Based Energy Evaluation:
E.C. Meng, B.K. Shoichet, and I.D. Kuntz, J. Comput. Chem.
13, 505 (1992).
- Determination of Molecular Topology and Atomic Hybridization
States from Heavy Atom Coordinates:
E.C. Meng and R.A. Lewis, J. Comput. Chem. 12, 891 (1991).
- A Novel Synthesis of Xanthines: Support for a New Binding Mode
for Xanthines with Respect to Adenosine at Adenosine Receptors:
N.P. Peet, N.L. Lentz, E.C. Meng, M.W. Dudley, A.M.L. Ogden, D.A. Demeter,
H.J.R. Weintraub, and P. Bey, J. Med. Chem. 33, 3127 (1990).
See also...
CV (lists all publications)
list of online resources for structure superposition
list of online resources for sequence alignments
GPCR data compilations
meng@cgl.ucsf.edu / June 2008
