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Command: boltz

Boltz is an artificial-intelligence method for predicting biomolecular structures containing proteins, RNA, DNA, and/or other molecules. Inspired by AlphaFold3, Boltz is fully open-source and freely available for both academic and commercial use under the MIT license. See:

Boltz-1 Democratizing Biomolecular Interaction Modeling. Wohlwend J, Corso G, Passaro S, Reveiz M, Leidal K, Swiderski W, Portnoi T, Chinn I, Silterra J, Jaakkola T, Barzilay R. bioRxiv [Preprint]. 2024 Dec 27:2024.11.19.624167.

See the ChimeraX Boltz example and video Boltz structure prediction in ChimeraX. See also: alphafold, esmfold, modeller

...under construction... see the ChimeraX Boltz example for command details


UCSF Resource for Biocomputing, Visualization, and Informatics / May 2025