Open session. Enable stereo. Enable space navigator.
Color domains
|
|
|
| Ring made from 6 copies of molecule.
Open session. Enable stereo. Enable space navigator. | Each copy has 3 movable parts.
Color domains |
| 
|
| One motion moves green domain.
Show domain motion.. | Another motion opens central pore in ring.
Show pore motion. |
| 
|
| Power source is ATP (red).
Show ATP. | An inhibitor (yellow) prevents the pore motion. |
| 
|
| Other drugs clotrimizole, astemizole, ebastine, CB-5083 inhibiting p97.
Show other drugs. | Locations of ATP energy source and inhibitor.
Show 6 copies. |
| 
|
| Mutation (pink) causing fronto-temporal dementia.
Show mutation | Adapter molecules npl4 (red) identifies molecules to recycle,
and p47 (orange) used in membrane fusion.
Show npl4 and p47. |