p97 Protein Recycling Machine

Ring made from 6 copies of molecule.
Open session. Enable stereo. Enable space navigator.
Each copy has 3 movable parts.
Color domains
One motion moves green domain.
Show domain motion..
Another motion opens central pore in ring.
Show pore motion.
Power source is ATP (red).
Show ATP.
An inhibitor (yellow) prevents the pore motion.
Other drugs clotrimizole, astemizole, ebastine, CB-5083 inhibiting p97.
Show other drugs.
Locations of ATP energy source and inhibitor.
Show 6 copies.
Mutation (pink) causing fronto-temporal dementia.
Show mutation
Adapter molecules npl4 (red) identifies molecules to recycle, and p47 (orange) used in membrane fusion.
Show npl4 and p47.