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Established in 1970, the Resource for Biocomputing, Visualization, and Informatics (RBVI) develops software and Web-based resources for the visualization and analysis of molecular structure at scales ranging from the atomic to the supramolecular. We create tools for handling and integrating diverse types of biomolecular data, including atomic-resolution coordinates, density maps, sequences, annotations, and networks. Our primary efforts are in the visualization and analysis of structures of molecules and molecular assemblies, enzyme sequence-structure-function relationships, and network representations of protein similarity, binding interactions, and biological pathways. We provide technologies to enable identifying the molecular bases of disease and phenotypic variation, annotating proteins of unknown function, identifying targets for drug development, designing drugs, and engineering proteins with new functions. The RBVI is an NIH/NIGMS Biomedical Technology Research Resource (BTRR).

Our Center distributes software tools, including the popular UCSF Chimera visualization and analysis package, develops and hosts the Structure-Function Linkage Database, and provides access to state-of-the-art computational resources in support of research projects in these areas. Our Center's history dates back to the earliest application of molecular graphics.

Our Center is organized around five key activities:

  1. Core research and development
  2. Collaborative research projects
  3. Development and access to visualization resources
  4. Outreach and training (workshops, meeting schedules, etc.)
  5. Dissemination and technology transfer

RBVI staff have formal training ranging from pharmaceutical chemistry to computer science and software engineering, and our Advisory Committee provides advice on research direction and priorities. For additional information, please contact Thomas Ferrin, RBVI Director, at tef [at] cgl.ucsf.edu.

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